Inhibition of Wnt signalling by Notch via two distinct mechanisms.

Download
2021-04-27
Acar, Ahmet
Hidalgo-Sastre, Ana
Leverentz, Michael K
Mills, Christopher G
Woodcock, Simon
Baron, Martin
Collu, Giovanna M
Brennan, Keith

Suggestions

INHIBITION OF CAMP-DEPENDENT PROTEIN-KINASE BY PHOSPHOENOL PYRUVATE
JAVED, MH; OZER, I (1987-06-01)
Activation of type I interferon-dependent genes characterizes the "core response" induced by CpG DNA.
Steinhagen, F; Meyer, C; Tross, D; Gürsel, Mayda; Maeda, T; Klaschik, S; Klinman, DM (2012-10-01)
Synthetic ODNs expressing CpG motifs trigger an innate immune response via TLR9. pDCs are major effectors of this response. Two structurally distinct classes of CpG ODNs have been identified that differentially activate pDCs. "K" ODNs trigger the production of TNF-alpha and IL-6, whereas "D" ODNs preferentially induce the secretion of IFN-alpha. As K and D ODNs have distinct therapeutic effects, knowledge of their shared and sequence-specific activity is of considerable importance. This work uses the CAL-1 ...
Inhibition of mackerel (Scomber scombrus) muscle lipoxygenase by green tea polyphenols
Banerjee, Sreeparna (Elsevier BV, 2006-01-01)
The high polyunsaturated fatty acid content of oily fish such as mackerel (Scomber scombrus) makes it particularly susceptible to oxidative degradation. We have shown previously the presence of lipoxygenase (LOX), a lipid oxygenase, in mackerel muscle. In the current study, commercially available green tea polyphenols were shown to effectively inhibit the LOX activity of mackerel muscle. EGCG (epigallocatechin gallate) was the strongest inhibitor tested with an IC50 (concentration for half maximal inhibitio...
Regulation of Abiotic Stress Signalling by Arabidopsis C-Terminal Domain Phosphatase-Like 1 Requires Interaction with a K-Homology Domain-Containing Protein
Jeong, In Sil; Fukudome, Akihito; Aksoy, Emre; Bang, Woo Young; Kim, Sewon; Guan, Qingmei; Bahk, Jeong Dong; May, Kimberly A.; Russell, William K.; Zhu, Jianhua; Koiwa, Hisashi (2013-11-01)
Arabidopsis thaliana CARBOXYL-TERMINAL DOMAIN (CTD) PHOSPHATASE-LIKE 1 (CPL1) regulates plant transcriptional responses to diverse stress signals. Unlike typical CTD phosphatases, CPL1 contains two double-stranded (ds) RNA binding motifs (dsRBMs) at its C-terminus. Some dsRBMs can bind to dsRNA and/or other proteins, but the function of the CPL1 dsRBMs has remained obscure. Here, we report identification of REGULATOR OF CBF GENE EXPRESSION 3 (RCF3) as a CPL1-interacting protein. RCF3 co-purified with tandem...
Regulation of CpG-induced immune activation by suppressive oligodeoxynucleotides.
Klinman, DM; Zeuner, R; Yamada, H; Gürsel, Mayda; Currie, D; Gursel, I (Wiley, 2003-12-01)
Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated "CpG motifs" stimulate an innate immune response characterized by the production of cytokines, chemokines, and polyreactive Igs that promote host survival following infectious challenge. Yet CpG-driven immune activation can have deleterious consequences, such as increasing the host's susceptibility to autoimmune disease. The immunomodulatory activity of CpG DNA can be blocked by DNA containing "suppressive" motifs. This work exp...
Citation Formats
A. Acar et al., “Inhibition of Wnt signalling by Notch via two distinct mechanisms.,” Scientific reports, pp. 9096–9096, 2021, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/90350.