Regulation of CpG-induced immune activation by suppressive oligodeoxynucleotides.

Date

2003-12-01

Author

Klinman, DM
Zeuner, R
Yamada, H
Gürsel, Mayda
Currie, D
Gursel, I

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Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated "CpG motifs" stimulate an innate immune response characterized by the production of cytokines, chemokines, and polyreactive Igs that promote host survival following infectious challenge. Yet CpG-driven immune activation can have deleterious consequences, such as increasing the host's susceptibility to autoimmune disease. The immunomodulatory activity of CpG DNA can be blocked by DNA containing "suppressive" motifs. This work explores the rules governing cellular recognition of stimulatory and suppressive motifs, and the resultant modulation of the immune system. Results suggest that both CpG and suppressive ODN may find use as therapeutic agents.

Subject Keywords

General Biochemistry, Genetics and Molecular Biology, History and Philosophy of Science

URI

https://hdl.handle.net/11511/48001

Journal

Annals of the New York Academy of Sciences

DOI

https://doi.org/10.1196/annals.1281.023

Collections

Department of Biology, Article

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Citation Formats

D. Klinman, R. Zeuner, H. Yamada, M. Gürsel, D. Currie, and I. Gursel, “Regulation of CpG-induced immune activation by suppressive oligodeoxynucleotides.,” Annals of the New York Academy of Sciences, pp. 112–23, 2003, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/48001.