Nanofeature Size and Morphology of Tantalum Oxide Surfaces Control Osteoblast Functions

Date

2021-01-01

Author

USLU, ECE
Mimiroğlu, Didem
Ercan, Batur

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

192
views

0
downloads

Tantalum is one of the most corrosion-resistant materials and has mechanical properties that are suitable for orthopedic applications. However, tantalum exhibits bioinert characteristics and cannot promote the desired level of osseointegration with juxtaposed bone tissues. To enhance the bioactivity of tantalum, nanoscale surface modifications via anodization could be a potential approach. In this study, surface features having nanotubular, nanodimple, and nanocoral morphologies were fabricated onto tantalum by controlling anodization parameters. Aside from altering the surface morphology, nanotubular, nanodimple, and nanocoral feature sizes were precisely fine-tuned between the 20 and 140 nm range. The results indicated that anodized surfaces consisted of Ta2O5 and nonstoichiometric tantalum suboxide chemistry. Upon the anodization, surface area of the tantalum samples increased up to 2-fold, which was accompanied by up to a 3.5-folds increase in the nanophase surface roughness. Biological studies showed that anodized tantalum surfaces significantly enhanced protein adsorption and improved bone cell proliferation and spreading independently of the anodized surface morphology and feature size. Nanodimple surfaces having a 90 nm feature size promoted 50% more bone cell proliferation and 23% more cellular spreading compared to non-anodized tantalum. Nanodimple surfaces also enhanced alkaline phosphatase activity and increased Ca mineral deposition up to 5 weeks compared to non-anodized tantalum, indicating higher bioactivity. In this study, biological interactions of anodized tantalum surfaces having different morphologies and feature sizes were examined, for the first time, and the potential use of nanostructured tantalum was highlighted for orthopedic applications.

URI

https://hdl.handle.net/11511/90723

Journal

ACS APPLIED BIO MATERIALS

DOI

https://doi.org/10.1021/acsabm.0c01354

Collections

Graduate School of Natural and Applied Sciences, Article

Suggestions

OpenMETU
Core

Microstructural and dielectric properties of naphthalene based polyamide/β-Ni(OH)2 nanocomposites Sezer, Selda; Öz, Erdinc; ALTIN, SERDAR; Vural, Sema; GÜLTEK, AHMET; KÖYTEPE, SÜLEYMAN; Nilüfer Kıvılcım, F. (2018-01-01) Background: Aromatic polyamides are important materials having outstanding thermal, electronic and mechanical properties among high performance polymers and industrial plastics. In addition, aromatic polyamides can be utilized in electronic devices with their low dielectric constant which indicates the storage capacity of these devices. Objective: Free volume is very important for dielectric materials and increase in free volume of a polymer reduces its dielectric constant. The aims of the current study are...
Multifunctional properties of polymer foams and composites Özkutlu Demirel, Merve; Bayram, Göknur; Department of Chemical Engineering (2020-9) Polymer foams are low-density materials that consist of solid and gas phases and are used for insulation and transportation applications. This study aims to produce poly(methyl methacrylate) (PMMA) foams with low density and improved thermal and mechanical properties using syntactic foam production and supercritical CO2 (scCO2) foaming methods. Syntactic foams were produced dispersing 5, 10, and 15 wt.% hollow glass microspheres (HGMs) in the PMMA matrix. Using different HGM types based on their density, su...
Surface modification of tantalum via anodization for orthopedic applications Uslu, Ece; Ercan, Batur; Department of Metallurgical and Materials Engineering (2020) Tantalum has excellent corrosion resistance and mechanical properties suitable for orthopedic applications. However, tantalum exhibits bioinert characteristics and cannot promote desired level of osseointegration with juxtaposed bone tissue. To enhance bioactivity of tantalum, nanoscale surface modification via anodization could be a potential approach. In this study, tantalum foils were modified to obtain surface features with different morphologies, i.e. nanotubular, nanodimple, nanoporous and nanocoral, ...
Polystyrene / boron nitride nanotube composites: synthesis, processing and characterization Balık, Erdem; Bayram, Göknur; Sezgi, Naime Aslı; Department of Chemical Engineering (2015) In recent years, boron nitride nanotubes (BNNTs) have been added to polystyrene (PS) which is a widely used thermoplastic polymer in order to improve its thermal and mechanical properties. Solution mixing and melt blending techniques are commonly used methods to prepare polymer-boron nitride nanotube (BNNT) composites. However, these two composite preparation methods have a common problem about the dispersion of fillers in the polymer matrix. In this study, PS-BNNT composites were prepared using masterbatch...
Sensitivity Analysis of Distortion of Carburized Steel Shafts Using Computer Simulations Yazır, Büşra; Evcil, Elif; Yıldız, Seçil; Davut, Kemal; Şimşir, Caner (null; 2016-12-01) Carburizing and subsequent quenching heat treatments are commonly used industrial processes to improve the properties and performance of steel shafts. Undesired dimensional and shape changes (distortion) related to these treatments are still the most frequent reason for expensive and time consuming corrective operations, low performance during service and even product rejection. The major aim of this study is to identify the suitable control parameters for subsequent optimization of the carburized quenching...

Citation Formats

E. USLU, D. Mimiroğlu, and B. Ercan, “Nanofeature Size and Morphology of Tantalum Oxide Surfaces Control Osteoblast Functions,” ACS APPLIED BIO MATERIALS, pp. 780–794, 2021, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/90723.