Fare Kök Hücrelerinden Başkalaştırılmış Bazal Ön Beyin Kolinerjik Nöronlarda TrkA Sinyalinin Artırılmasının in vitro Alzheimer Hastalığını Nörodejeneratif Sürecine Karşı Etkisinin Kontrollere Kıyasla Araştırılması

2021-11-22

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Mouse embryonic stem cells (mESCs) are pluripotent cells that have self renewal capability. They can differentiate into all three primary germ layers: mesoderm, endoderm, and ectoderm during embryonic development. The embryonic development is controlled via spatiotemporal regulation of gene expression changes. The collaborative effects of Wnt, Nodal, BMP signaling pathways help form the primitive streak, and the subsequent definitive endoderm layer in the gastrulating embryo. Deactivation of core pluripoten...
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Embryonic development is a highly coordinated process that contains rapid cell divisions. During this time, the cells also start differentiation, and at the end of development, the cells become fully differentiated. This differentiation commitment is regulated by epigenetic factors like histone modifiers, chromatin regulators. SETD3 is one of the histone methyltransferases that govern this pluripotency-differentiation balance. We have previously found that SETD3 is crucial for mesendoderm differentiation of...
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Ceylani, Taha; Gözen, Ayşe Gül; Doğru, Ewa; Department of Biology (2018)
Recently arising studies with animal models show that there is a bidirectional communication between gut microbiota and central nervous system (CNS) through neural, endocrine and immune pathways which influences brain function and behavior. Apparently, gut microbiota may play a role in the regulation of anxiety, mood, cognition, and pain sensation. Gut microbiota may cause gastrointestinal disorders, such as irritable bowel syndrome (IBS), which can be comorbid with stress-related psychiatric conditions inf...
Citation Formats
S. Ezgin and E. Kiriş, “Fare Kök Hücrelerinden Başkalaştırılmış Bazal Ön Beyin Kolinerjik Nöronlarda TrkA Sinyalinin Artırılmasının in vitro Alzheimer Hastalığını Nörodejeneratif Sürecine Karşı Etkisinin Kontrollere Kıyasla Araştırılması,” presented at the 19. Ulusal Sinirbilim Kongresi, Online, Türkiye, 2021, Accessed: 00, 2022. [Online]. Available: http://usktubas.org/wp-content/uploads/2021/11/19.-USK-KI%CC%87TAPC%CC%A7IK-.pdf.