Fare Kök Hücrelerinden Başkalaştırılmış Bazal Ön Beyin Kolinerjik Nöronlarda TrkA Sinyalinin Artırılmasının in vitro Alzheimer Hastalığını Nörodejeneratif Sürecine Karşı Etkisinin Kontrollere Kıyasla Araştırılması

2021-11-22

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SETD3-dependent gene expression changes during endoderm differentiation of mouse embryonic stem cells
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Embryonic development is a process that is highly regulated at the level of gene expression. Throughout this process, the zygote divides and differentiates to form all cell types in the adult body. In the early stages of development, pluripotent embryonic stem cells (ESC) can be isolated and used to study cell fate mechanisms during development in vitro. The pluripotency of ESCs is governed by certain transcription factors (TF) (Oct4, Nanog, etc.). These TFs construct a transcription network specific to ESC...
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Identification of protein partners of setd3 in mouse embryonic stem cells
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Embryonic development is a highly coordinated process that contains rapid cell divisions. During this time, the cells also start differentiation, and at the end of development, the cells become fully differentiated. This differentiation commitment is regulated by epigenetic factors like histone modifiers, chromatin regulators. SETD3 is one of the histone methyltransferases that govern this pluripotency-differentiation balance. We have previously found that SETD3 is crucial for mesendoderm differentiation of...
Citation Formats
S. Ezgin and E. Kiriş, “Fare Kök Hücrelerinden Başkalaştırılmış Bazal Ön Beyin Kolinerjik Nöronlarda TrkA Sinyalinin Artırılmasının in vitro Alzheimer Hastalığını Nörodejeneratif Sürecine Karşı Etkisinin Kontrollere Kıyasla Araştırılması,” presented at the 19. Ulusal Sinirbilim Kongresi, Online, Türkiye, 2021, Accessed: 00, 2022. [Online]. Available: http://usktubas.org/wp-content/uploads/2021/11/19.-USK-KI%CC%87TAPC%CC%A7IK-.pdf.