A computational model to investigate the effect of dopamine on neural synchronization in striatum

Date

2015-09-28

Author

Elibol, Rahmi
Şengör, Neslihan Serap

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© 2015 IEEE.Synchronous behavior of neural populations has been related to cognitive processes as attention, learning and has been considered as hallmarks of neurological disorders. The computational models of neural structures, even the simple ones, could give informative results which can improve our understanding of cognitive processes, arising due to collective activity of neurons. Here, a neurocomputational model for investigating the role of dopamine level on the synchronized behavior of medium spiny neurons in striatum is given.The model is composed of point neurons and dynamic synaptic connections and the excitatory connections of medium spiny neurons are modulated according to spike time dependent plasticity rule. The results convey that dopamine level has opposite effect on the synchronization of D1 and D2 type medium spiny neuron populations. Also, it is shown that spike timing dependent plasticity enhances the synchronized behavior.

Subject Keywords

Electroencephalography, Physiology

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84951200303&origin=inward
https://hdl.handle.net/11511/98399

DOI

https://doi.org/10.1109/ijcnn.2015.7280762

Conference Name

International Joint Conference on Neural Networks, IJCNN 2015

Collections

Graduate School of Informatics, Conference / Seminar

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Citation Formats

R. Elibol and N. S. Şengör, “A computational model to investigate the effect of dopamine on neural synchronization in striatum,” Killarney, İrlanda, 2015, vol. 2015-September, Accessed: 00, 2022. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84951200303&origin=inward.