Selective monitoring and treatment of neuroblastoma cells with hydrogen sulfide activatable phototheranostic agent

Date

2023-02-01

Author

Dirak, Musa
Kepil, Dilay
Almammadov, Toghrul
Elmazoglu, Zubeyir
Cetin, Sultan
Ozogul, Naz
Günbaş, Emrullah Görkem
Kolemen, Safacan

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

140
views

0
downloads

Activity-based photosensitizers (aPSs) are highly attractive as they offer improved selectivity and better therapeutic outcome in the scope of photodynamic therapy (PDT). Here, a hydrogen sulfide (H2S) responsive iodinated resorufin-based PS (RHS) was developed to treat neuroblastoma cancer cells selectively. RHS was shown to be a phototheranostic agent as it turned on its fluorescence signal and singlet oxygen (1O2) generation capability after reacting with H2S. RHS exhibited remarkable sensitivity towards H2S and proved to be highly cytotoxic in H2S rich SH-SY5Y human neuroblastoma cells upon light irradiation. In contrast, no photocytotoxicity was observed in H2S deficient nonmalignant fibroblast L929 cells. RHS marks the first example of a resorufin-based H2S activatable phototheranostic agent, which paves the way for effective treatment of neuroblastoma through PDT modality.

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85143876489&origin=inward
https://hdl.handle.net/11511/101511

Journal

Dyes and Pigments

DOI

https://doi.org/10.1016/j.dyepig.2022.111011

Collections

Department of Chemistry, Article

Suggestions

OpenMETU
Core

EFFORTS TOWARDS SYNTHESIS OF HYDROGEN SULFIDE ACTIVATED BODIPY BASED PDT AGENT Canyurt, Merve; Günbaş, Emrullah Görkem; Department of Chemistry (2022-5-13) Photodynamic Therapy (PDT) is an effective and minimally invasive method that has recently gained widespread acceptance as a new medical treatment for a variety of conditions. PDT uses photosensitizers in combination with a specific light source and molecular oxygen to form cytotoxic species that can damage organelles and cell membranes directly. The photodynamic reactions start with light absorption by the PS in the target tissue, which sets off a chain of photochemical events. In comparison to existing se...
Computerized hybrid decision-making system for hormone replacement therapy in menopausal women Bacak, Hikmet Özge; Leblebicioğlu, Mehmet Kemal; TANAÇAN, ATAKAN; BEKSAÇ, MEHMET SİNAN (IOS Press, 2019-01-01) BACKGROUND: The diversity of the results of different hormone replacement therapy (HRT) protocols and the fuzziness of the conclusions have caused problems in routine clinical practice.
Integrative Predictive Modeling of Metastasis in Melanoma Cancer Based on MicroRNA, mRNA, and DNA Methylation Data Kutlay, Aysegul; Aydın Son, Yeşim (2021-09-01) Introduction: Despite the significant progress in understanding cancer biology, the deduction of metastasis is still a challenge in the clinic. Transcriptional regulation is one of the critical mechanisms underlying cancer development. Even though mRNA, microRNA, and DNA methylation mechanisms have a crucial impact on the metastatic outcome, there are no comprehensive data mining models that combine all transcriptional regulation aspects for metastasis prediction. This study focused on identifying the regul...
Improving the Computer-Aided Estimation of Ulcerative Colitis Severity According to Mayo Endoscopic Score by Using Regression-Based Deep Learning Polat, Gorkem; Kani, Haluk Tarik; Ergenc, Ilkay; Alahdab, Yesim Ozen; Temizel, Alptekin; Atug, Ozlen (2022-11-01) Background Assessment of endoscopic activity in ulcerative colitis (UC) is important for treatment decisions and monitoring disease progress. However, substantial inter- and intraobserver variability in grading impairs the assessment. Our aim was to develop a computer-aided diagnosis system using deep learning to reduce subjectivity and improve the reliability of the assessment. Methods The cohort comprises 11 276 images from 564 patients who underwent colonoscopy for UC. We propose a regression-based deep ...
Time-Limited Counseling Outcome in Nationwide College Counseling Center Sample Drapper, Matt; Jennings, J.; Baron, A.; Erdur Baker, Özgür (2002-07-01) This study examined the dose‐effect relationship between the number of sessions and therapeutic outcome in a large, nationwide counseling center research consortium. A positive relationship was found between the outcome of counseling and the number of sessions attended. The results of this study support the effectiveness of brief psychotherapy.

Citation Formats

M. Dirak et al., “Selective monitoring and treatment of neuroblastoma cells with hydrogen sulfide activatable phototheranostic agent,” Dyes and Pigments, vol. 210, pp. 0–0, 2023, Accessed: 00, 2023. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85143876489&origin=inward.