Selective monitoring and treatment of neuroblastoma cells with hydrogen sulfide activatable phototheranostic agent

Date

2023-02-01

Author

Dirak, Musa
Kepil, Dilay
Almammadov, Toghrul
Elmazoglu, Zubeyir
Cetin, Sultan
Ozogul, Naz
Günbaş, Emrullah Görkem
Kolemen, Safacan

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Activity-based photosensitizers (aPSs) are highly attractive as they offer improved selectivity and better therapeutic outcome in the scope of photodynamic therapy (PDT). Here, a hydrogen sulfide (H2S) responsive iodinated resorufin-based PS (RHS) was developed to treat neuroblastoma cancer cells selectively. RHS was shown to be a phototheranostic agent as it turned on its fluorescence signal and singlet oxygen (1O2) generation capability after reacting with H2S. RHS exhibited remarkable sensitivity towards H2S and proved to be highly cytotoxic in H2S rich SH-SY5Y human neuroblastoma cells upon light irradiation. In contrast, no photocytotoxicity was observed in H2S deficient nonmalignant fibroblast L929 cells. RHS marks the first example of a resorufin-based H2S activatable phototheranostic agent, which paves the way for effective treatment of neuroblastoma through PDT modality.

URI

https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85143876489&origin=inward
https://hdl.handle.net/11511/101511

Journal

Dyes and Pigments

DOI

https://doi.org/10.1016/j.dyepig.2022.111011

Collections

Department of Chemistry, Article

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Citation Formats

M. Dirak et al., “Selective monitoring and treatment of neuroblastoma cells with hydrogen sulfide activatable phototheranostic agent,” Dyes and Pigments, vol. 210, pp. 0–0, 2023, Accessed: 00, 2023. [Online]. Available: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85143876489&origin=inward.