Interrupted processing of paired somatosensory stimuli in short interstimulus intervals: role of thalamo-cortical oscillations

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2022-1-01

Author

Tepe, Nermin
BORAN, HÜRREM EVREN
Gedük, Salih
DİLEKÖZ, ERGİN
Ulusoy, İlkay
BELEN, HAYRUNNİSA BOLAY

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Background/aim: Discrimination of consecutive sensory stimuli is imperative for proper sensory perception and behavioral response. We aimed to investigate the emergence of paired somatosensory responses in relation to the interstimulus interval (ISI) change. Materials and methods: Paired stimulus with 35 ms, 50 ms, 80 ms, 140 ms, and 500 ms ISI was applied to the median nerve and evoked responses were recorded from the primary somatosensory cortex in rats. Early and late components of both responses were analyzed in different frequency bands. Results: The amplitudes were comparable for the 1st responses (S1), while the amplitude of the 2nd responses (S2), and S2/S1 sensory gating ratio were significantly lower at 35 and 50 ms ISI values. S2/S1 ratio was close to 1 at 500 ms ISI. The duration and latency of the 2nd response was also different at 35 ms ISI. In the 2nd responses, area of early high-frequency oscillations (150–400 Hz) was significantly lower at 35 ms ISI values. Conclusion: The shaping of 2nd somatosensory response is dependent on ISIs. Early high-frequency oscillations changes without accompanying late high-frequency oscillations alterations, may indicate that reduced thalamo-cortical drive to the cortex take a part in determining the 2nd response at short ISI. Further research is required by using neuropsychiatric disorder models where somatosensory perception is impaired.

Subject Keywords

Paired-pulse somatosensory evoked potentials, interstimulus interval, thalamus, high-frequency oscillations, sensory gating, HIGH-FREQUENCY OSCILLATIONS, TEMPORAL DISCRIMINATION, RECOVERY FUNCTIONS, RECEPTIVE-FIELDS, MIGRAINE, COMPONENTS, RESPONSES, CORTEX, high-frequency oscillations, interstimulus interval, Paired-pulse somatosensory evoked potentials, sensory gating, thalamus

URI

https://hdl.handle.net/11511/101862

Journal

Turkish Journal of Medical Sciences

DOI

https://doi.org/10.55730/1300-0144.5444

Collections

Department of Electrical and Electronics Engineering, Article

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Citation Formats

N. Tepe, H. E. BORAN, S. Gedük, E. DİLEKÖZ, İ. Ulusoy, and H. B. BELEN, “Interrupted processing of paired somatosensory stimuli in short interstimulus intervals: role of thalamo-cortical oscillations,” Turkish Journal of Medical Sciences, vol. 52, no. 4, pp. 1371–1377, 2022, Accessed: 00, 2023. [Online]. Available: https://hdl.handle.net/11511/101862.