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Methods to improve antibacterial properties of PEEK: A review
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Date
2024-03-01
Author
Uysal, Idil
Tezcaner, Ayşen
Evis, Zafer
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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As a thermoplastic and bioinert polymer, polyether ether ketone (PEEK) serves as spine implants, femoral stems, cranial implants, and joint arthroplasty implants due to its mechanical properties resembling the cortical bone, chemical stability, and radiolucency. Although there are standards and antibiotic treatments for infection control during and after surgery, the infection risk is lowered but can not be eliminated. The antibacterial properties of PEEK implants should be improved to provide better infection control. This review includes the strategies for enhancing the antibacterial properties of PEEK in four categories: immobilization of functional materials and functional groups, forming nanocomposites, changing surface topography, and coating with antibacterial material. The measuring methods of antibacterial properties of the current studies of PEEK are explained in detail under quantitative, qualitative, and in vivo methods. The mechanisms of bacterial inhibition by reactive oxygen species generation, contact killing, trap killing, and limited bacterial adhesion on hydrophobic surfaces are explained with corresponding antibacterial compounds or techniques. The prospective analysis of the current studies is done, and dual systems combining osteogenic and antibacterial agents immobilized on the surface of PEEK are found the promising solution for a better implant design.
Subject Keywords
antibacterial rate
,
biomedical applications
,
PEEK
,
surface modifications
URI
https://hdl.handle.net/11511/109059
Journal
Biomedical Materials (Bristol)
DOI
https://doi.org/10.1088/1748-605x/ad2a3d
Collections
Department of Engineering Sciences, Article
Citation Formats
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BibTeX
I. Uysal, A. Tezcaner, and Z. Evis, “Methods to improve antibacterial properties of PEEK: A review,”
Biomedical Materials (Bristol)
, vol. 19, no. 2, pp. 0–0, 2024, Accessed: 00, 2024. [Online]. Available: https://hdl.handle.net/11511/109059.