A novel synthesis of substituted 2H-pyran-2-one derivatives

Karaaslan Ürkmez, Rezzan


Synthesis and spectroscopic investigations of some carbonyl-olefin-metal (0) complexes of group 68 elements
Mour, İzzet A; Özkar, Saim; İşçi, Hüseyin; Department of Chemistry (1992)
Chemoenzymatic functionalization of cyclic 1,3-diketones
Fındık, Hamide; Demir, Ayhan Sıtkı; Department of Chemistry (2004)
Chiral a-hydroxy and a-acetoxy enones are important starting materials in the synthesis of many biologically active materials. In this work, enantiomerically pure ?-hydroxy enone and polyoxo cyclohexenones are synthesized starting from 1,3-cyclohexandione. In the first step, 1,3-cyclohexandione is protected under acid catalyzation and 3-methoxy-2-methyl-2-cyclohexen-1-one is obtained. a'-Acetoxy enone is obtained by Mn(OAc)3 mediated oxidation which is an attractive alternative to other multi-step procedure...
Synthesis, stereochemistry and reactivity of diimine-carbonylmental (0) complexes of 6B elements
Kayran, Ceyhan; Özkar, Saim; Department of Chemistry (1991)
Chemoenzymatic synthesis of 4-hydroxy enones
Köse, Elif; Demir, Ayhan Sıtkı; Department of Chemistry (2004)
Chiral cyclic polyoxo-ketones are important structural units in many natural products, biologically active compouds, such as prostaglandins, didemnenones, sarkomycin, punaglandin, clavulone, etc. In this work, a chemoenzymatic synthesis of both enantiomers of the a̕-acetoxy-a-methyl and ?-hydroxy-a-methyl cyclic enones starting from a-methyl-β-methoxy cyclic enone is described. Manganese (III) acetate-mediated acetoxylation followed by the enzyme-mediated hydrolysis of a̕-acetoxy enone provides acetoxy enon...
Novel conversion of thiols into disulfides, via S-nitrosothiol intermediates using trichloronitromethane
Demir, Ayhan Sıtkı; Igdir, AC; Mahasneh, AS (1999-10-15)
An efficient oxidative coupling of thiols to give disulfides via thionitrite (S-nitrosothiol) intermediate is described using trichloronitromethane as an efficient reagent in organic solvents and water. Cysteine and glutathione are converted into the corresponding disulfides in water in high yields.
Citation Formats
R. Karaaslan Ürkmez, “A novel synthesis of substituted 2H-pyran-2-one derivatives,” Ph.D. - Doctoral Program, Middle East Technical University, 1992.