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Novel conversion of thiols into disulfides, via S-nitrosothiol intermediates using trichloronitromethane

Demir, Ayhan Sıtkı
Igdir, AC
Mahasneh, AS
An efficient oxidative coupling of thiols to give disulfides via thionitrite (S-nitrosothiol) intermediate is described using trichloronitromethane as an efficient reagent in organic solvents and water. Cysteine and glutathione are converted into the corresponding disulfides in water in high yields.