Novel conversion of thiols into disulfides, via S-nitrosothiol intermediates using trichloronitromethane

Demir, Ayhan Sıtkı
Igdir, AC
Mahasneh, AS
An efficient oxidative coupling of thiols to give disulfides via thionitrite (S-nitrosothiol) intermediate is described using trichloronitromethane as an efficient reagent in organic solvents and water. Cysteine and glutathione are converted into the corresponding disulfides in water in high yields.


Generation of aryl radicals from arylboronic acids by manganese(III) acetate: Synthesis of biaryls and heterobiaryls
Demir, Ayhan Sıtkı; Reis, O; Emrullahoglu, M (2003-01-24)
The efficient generation of aryl radicals from arylboronic acids by manganese(III) acetate is described. In aromatic solvents, in situ generated aryl radicals afford the corresponding biaryls in very good yields. This method works selectively, and yields are better than those from similar, previously described methods. Arylboronic acids carrying sensitive functional groups also work efficiently.
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Topal, Tansel; Tuncel, Semra G.; Department of Chemistry (2011)
The extraction procedures for the determination of polycyclic aromatic hydrocarbons (PAH) concentrations in sediment samples had been developed by using GC-FID and GC-MS. The optimized methods were soxhlet extraction, ultrasonic bath extraction and solid phase micro extraction (SPME). In order to search out the main factors affecting extraction efficiencies of the methods, factorial design was used. The best extraction method was chosen and optimum values for main factors were selected for the development o...
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Arslan, Yasin; Ataman, Osman Yavuz; Department of Chemistry (2011)
A novel analytical technique was developed where gaseous hydrogen selenide formed by sodium tetrahydroborate reduction is transported to and trapped on a resistively heated gold-coated W-coil atom trap for in situ preconcentration. The atom trap is held at 165 ºC during the collection stage and is heated up to 675 ºC for revolatilization; analyte species formed are transported to an externally heated quartz T-tube where the atomization takes place and the transient signal is obtained. For gold, a high volum...
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Kıvrak, Arif; Zora, Metin; Department of Chemistry (2011)
Synthesis of five-membered heteroaromatic compounds such as pyrazoles, isoxazoles and 1,2,4-oxadiazoles are important for pharmaceutical industry and material science due to their applications. Although there are many methods to prepare such compounds, new variants continue to appear since they exhibit a wide range of biological and medicinal activities. In this thesis, new methods were developed for the synthesis of 4-iodopyrazoles, pyrazoles, isoxazoles, 1,2,4-oxadiazoles and/or 1,2,4-oxadiazepines. In th...
Epoxidation reactions of small alkenes on catalytic surfaces
Kurnaz, Emine; Önal, Işık; Department of Chemical Engineering (2011)
Propylene epoxidation reaction was investigated on catalytic surfaces of chlorinated copper(I) oxide and ruthenium(IV) oxide using periodic density functional theory (DFT). Cu2O(001) and (110) surface of RuO2 was selected to generate chlorinated surfaces to be used in the study. Besides epoxidation, other reactions that compete with epoxidation were also studied such as formations of allyl-radical, acrolein, acetone on chlorinated Cu2O(001) and formations of propionaldehyde, allyl-radical and acetone on chl...
Citation Formats
A. S. Demir, A. Igdir, and A. Mahasneh, “Novel conversion of thiols into disulfides, via S-nitrosothiol intermediates using trichloronitromethane,” TETRAHEDRON, pp. 12399–12404, 1999, Accessed: 00, 2020. [Online]. Available: