Genotoxicity of methylene chloride: effects of glutathione S-Transferase theta polymorphism on induction of SCE in lymphocytes

Topsoy, Serap


Genotoxicity studies on benzimidazole retinoids
Balaban, F; Ates-Alagoz, Z; Buyukbingol, E; İşcan, Mesude (2005-11-01)
Retinoids consist of a family of naturally occuring compounds including all-trans retinoic acid (ATRA), retinal, retinol (vitamin A), 9-cis retinoic acid, 13-cis retinoic acid as well as a large number of synthetic derivatives. Retinoids are known to elicit diverse pharmacological profiles such as controlling cell differentiation/proliferation and modulating specific premalignant lesions and reducing second primary tumors in patients. Clinical use of retinoids is limited due to their toxicity. Three benzimi...
Genotoxicity studies of tetrahydro-naphthalene-benzimidazole/thiazolidinedione as retinoid derivatives
Doğan, Tuğba; Ates-Alagoz, Zeynep; Buyukbingol, Erdem (2015-11-01)
Objective: Mutagenicity is an undesirable side effect of clinically prescribed drugs, thus raises the question of their potential carcinogenicity. Taking into account that nitro compounds are known for their genotoxicity, it will be considerable interest to assess the genotoxic activities of the benzimidazole/thiazolidinedione retinoid derivatives. For this reason, the present study reports the genotoxicity of previously synthesized benzimidazole/thiazolidinedione-retinoid derivatives (Ates-Alagoz and Buyuk...
Genotoxicity studies on newly synthesized retinoids
Balaban, Fulya; İşcan, Mesude; Department of Biochemistry (2000)
Genotoxicity in human lymphocytes and rat tissues exposed to cadmium and nickel alone or in combination.
Şaplakoğlu, Adile Umay; İşcan, Mesude; Department of Biology (1996)
Genotoxicity of potent antiviral 1-[(2-aminophenyl)thio]-1-phenyl-2-nitrobutane derivatives designed as drug agents
Doğan, Tuğba; Gokce, Mehtap; ÖZTÜRK, KAMİLE (2014-01-01)
Objective: Genotoxic potentials of six selected nitrobutane (I) derivatives designed as drug agents were tested here for the first time using umu-microplate test system. An important principle in drug development is to perform safety tests of previously determined significant drug activity in in vitro assays. This may be even more crucial than its efficiency in terms of experimental conditions, since it is important in chemotherapy to treat without risk for the patient.
Citation Formats
S. Topsoy, “Genotoxicity of methylene chloride: effects of glutathione S-Transferase theta polymorphism on induction of SCE in lymphocytes,” Middle East Technical University, 1997.