Genotoxicity studies of tetrahydro-naphthalene-benzimidazole/thiazolidinedione as retinoid derivatives

Doğan, Tuğba
Ates-Alagoz, Zeynep
Buyukbingol, Erdem
Objective: Mutagenicity is an undesirable side effect of clinically prescribed drugs, thus raises the question of their potential carcinogenicity. Taking into account that nitro compounds are known for their genotoxicity, it will be considerable interest to assess the genotoxic activities of the benzimidazole/thiazolidinedione retinoid derivatives. For this reason, the present study reports the genotoxicity of previously synthesized benzimidazole/thiazolidinedione-retinoid derivatives (Ates-Alagoz and Buyukbingol, 2001; Ates-Alagoz et. al., 2009) by the umu-microplate test system.


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The mechanism of weight gain through application of olanzapine, a serotonin and dopamine receptor antagonist has not been fully understood. Weight gain and food intake are under the control of various neurohormones; POMC (proopiomelanocortin), CART (cocaine and amphetamine regulated transcript), AgRP (Agouti-related peptide) and NPY (neuropeptide Y) that are majorly synthesized and secreted from the arcuate nucleus (ARC) of hypothalamus. In this study, the alteration of the ARC neurohormone levels in rats w...
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Objective: Genotoxic potentials of six selected nitrobutane (I) derivatives designed as drug agents were tested here for the first time using umu-microplate test system. An important principle in drug development is to perform safety tests of previously determined significant drug activity in in vitro assays. This may be even more crucial than its efficiency in terms of experimental conditions, since it is important in chemotherapy to treat without risk for the patient.
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Şanlı, Samet; Önal, Ahmet Muhtar; Volkan, Mürvet; Department of Polymer Science and Technology (2018)
In this study, the main goal was to prepare new modified electrodes to be used in the dopamine (DA) determination in the presence of ascorbic acid (AA). For this purpose, the surface of glassy carbon electrodes (GCE) were modified with poly(3,4-ethylenedioxythiophene) (PEDOT), polyoxometalate (POM) doped PEDOT, poly (9-amino fluorene) (P9AF) and poly(9-fluorene carboxylic acid) (PFCA) by using electrochemical polymerization method. The modified electrodes were used as a working electrode in the presence of ...
Citation Formats
T. Doğan, Z. Ates-Alagoz, and E. Buyukbingol, “Genotoxicity studies of tetrahydro-naphthalene-benzimidazole/thiazolidinedione as retinoid derivatives,” TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, pp. 500–507, 2015, Accessed: 00, 2020. [Online]. Available: