Genotoxicity studies of tetrahydro-naphthalene-benzimidazole/thiazolidinedione as retinoid derivatives

Date

2015-11-01

Author

Doğan, Tuğba
Ates-Alagoz, Zeynep
Buyukbingol, Erdem

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Objective: Mutagenicity is an undesirable side effect of clinically prescribed drugs, thus raises the question of their potential carcinogenicity. Taking into account that nitro compounds are known for their genotoxicity, it will be considerable interest to assess the genotoxic activities of the benzimidazole/thiazolidinedione retinoid derivatives. For this reason, the present study reports the genotoxicity of previously synthesized benzimidazole/thiazolidinedione-retinoid derivatives (Ates-Alagoz and Buyukbingol, 2001; Ates-Alagoz et. al., 2009) by the umu-microplate test system.

Subject Keywords

Retinoids, Tetrahydro-naphthalene, Benzimidazole, Thiazolidinedione, Genotoxicity, Umu microplate test

URI

https://hdl.handle.net/11511/32978

Journal

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI

DOI

https://doi.org/10.1515/tjb-2015-0041

Collections

Test and Measurement Center In advanced Technologies (MERKEZ LABORATUVARI), Article

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Citation Formats

T. Doğan, Z. Ates-Alagoz, and E. Buyukbingol, “Genotoxicity studies of tetrahydro-naphthalene-benzimidazole/thiazolidinedione as retinoid derivatives,” TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, pp. 500–507, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32978.