Genotoxicity of potent antiviral 1-[(2-aminophenyl)thio]-1-phenyl-2-nitrobutane derivatives designed as drug agents

Doğan, Tuğba
Gokce, Mehtap
Objective: Genotoxic potentials of six selected nitrobutane (I) derivatives designed as drug agents were tested here for the first time using umu-microplate test system. An important principle in drug development is to perform safety tests of previously determined significant drug activity in in vitro assays. This may be even more crucial than its efficiency in terms of experimental conditions, since it is important in chemotherapy to treat without risk for the patient.


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The hydrothermally synthesized SBA-15 particles were surface functionalized by post-grafting synthesis method with (3-aminopropyl) triethoxy silane, mercaptopropyl trimethoxy silane and triethoxy methyl silane in order to be used as carrier materials for drug delivery. Amoxicillin was used as a model drug. The adsorption and release properties of calcined and organic-functionalized mesoporous silicas containing terminal primary amine, organothiol and methyl groups toward amoxicillin have been investigated. ...
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Tugluk, Ozan; Tarman, Işık Hakan (2012-05-01)
In this study, a numerical method based on solenoidal basis functions, for the simulation of incompressible flow through a circular-cylindrical pipe, is presented. The solenoidal bases utilized in the study are formulated using the Legendre polynomials. Legendre polynomials are favorable, both for the form of the basis functions and for the inner product integrals arising from the Galerkin-type projection used. The projection is performed onto the dual solenoidal bases, eliminating the pressure variable, si...
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The purpose of this study was to apply the optimization method incorporating artificial neural network (ANN) using pH-independent release of weakly basic drug, carvedilol from HPMC-based matrix formulation. Because of weakly basic nature of carvedilol, drug shows pH-dependent solubility. The enteric polymer EUDRAGIT L100 was added formulations to overcome pH-dependent solubility of carvedilol. Effects of the Hydroxypropylmethyl cellulose (HPMC) K4M and EUDRAGIT L100 amount on drug release were investigated....
Synthesis of bistriphenylamine- and benzodithiophene-based random conjugated polymers for organic photovoltaic applications
CETIN, Asli; ISTANBULLUOGLU, Cagla; HACIOGLU, Serife Ozdemir; CEVHER, ŞEVKİ CAN; Toppare, Levent Kamil; Çırpan, Ali (2017-11-15)
In this study, donor-acceptor random polymers containing benzotriazole acceptor and bistriphenylamine and benzodithiophene donors, P1 and P2, were successfully synthesized by Stille coupling polymerization. The effect of bistriphenylamine moiety and thiophene -conjugated linker on electrochemical, spectroelectrochemical, and optical behaviors of the polymers were investigated. Optoelectronic properties and photovoltaic performance of the polymers were examined under the illumination of AM 1.5G, 100 mWcm(-2)...
YILDIRIM, F; KORASLI, C (1992-12-01)
Several goodness-of-fit test procedures were applied to dc-breakdown conditioning test results, obtained in SF6 at 0.4 MPa in concentric-coaxial systems, and to other published data to determine whether the three-parameter Weibull distribution is the only match. The three-parameter Weibull distribution was found to be the best suited among other probabilistic exponential distributions representing the area-dependent statistical characteristics of compressed-gas insulated systems. Parameters of the three-par...
Citation Formats
T. Doğan, M. Gokce, and K. ÖZTÜRK, “Genotoxicity of potent antiviral 1-[(2-aminophenyl)thio]-1-phenyl-2-nitrobutane derivatives designed as drug agents,” TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, pp. 328–335, 2014, Accessed: 00, 2020. [Online]. Available: