Genotoxicity of potent antiviral 1-[(2-aminophenyl)thio]-1-phenyl-2-nitrobutane derivatives designed as drug agents

Date

2014-01-01

Author

Doğan, Tuğba
Durusoy, Mubeccel
Gokce, Mehtap
ÖZTÜRK, KAMİLE

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Objective: Genotoxic potentials of six selected nitrobutane (I) derivatives designed as drug agents were tested here for the first time using umu-microplate test system. An important principle in drug development is to perform safety tests of previously determined significant drug activity in in vitro assays. This may be even more crucial than its efficiency in terms of experimental conditions, since it is important in chemotherapy to treat without risk for the patient.

Subject Keywords

Nitro compounds, Umu-microplate, Genotoxicity, Drug

URI

https://hdl.handle.net/11511/49165

Journal

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI

DOI

https://doi.org/10.5505/tjb.2014.25238

Collections

Test and Measurement Center In advanced Technologies (MERKEZ LABORATUVARI), Article

Citation Formats

T. Doğan, M. Durusoy, M. Gokce, and K. ÖZTÜRK, “Genotoxicity of potent antiviral 1-[(2-aminophenyl)thio]-1-phenyl-2-nitrobutane derivatives designed as drug agents,” TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol. 39, no. 3, pp. 328–335, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/49165.