Genotoxicity of potent antiviral 1-[(2-aminophenyl)thio]-1-phenyl-2-nitrobutane derivatives designed as drug agents

2014-01-01
Doğan, Tuğba
Gokce, Mehtap
ÖZTÜRK, KAMİLE
Objective: Genotoxic potentials of six selected nitrobutane (I) derivatives designed as drug agents were tested here for the first time using umu-microplate test system. An important principle in drug development is to perform safety tests of previously determined significant drug activity in in vitro assays. This may be even more crucial than its efficiency in terms of experimental conditions, since it is important in chemotherapy to treat without risk for the patient.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI

Suggestions

Surface functionalization of SBA-15 particles for amoxicillin delivery
Sevimli, Filiz; Yılmaz, Ayşen (2012-08-01)
The hydrothermally synthesized SBA-15 particles were surface functionalized by post-grafting synthesis method with (3-aminopropyl) triethoxy silane, mercaptopropyl trimethoxy silane and triethoxy methyl silane in order to be used as carrier materials for drug delivery. Amoxicillin was used as a model drug. The adsorption and release properties of calcined and organic-functionalized mesoporous silicas containing terminal primary amine, organothiol and methyl groups toward amoxicillin have been investigated. ...
Capillary electrophoresis with online stacking in combination with AgNPs@MCM-41 reinforced hollow fiber solid-liquid phase microextraction for quantitative analysis of Capecitabine and its main metabolite 5-Fluorouracil in plasma samples isolated from cancer patients
Forough, Mehrdad; Farhadi, Khalil; Molaei, Rahim; Khalili, Hedayat; Shakeri, Ramin; Zamani, Asghar; Matin, Amir Abbas (2017-01-01)
The purpose of this study is the development and validation of a simple, novel, selective and fast off-line microextraction technique combining capillary electrophoresis with in-column field-amplified sample injection (FASI) for the simultaneous determination of capecitabine (CAP) and its active metabolite, 5-Fluorouracil (5-FU), in human plasma. At the moment, there is a lack of using cost-effective CE tool combined with novel miniaturized sample clean-up techniques for analysis of these important anticanc...
Systematic development of pH-independent controlled release tablets of carvedilol using central composite design and artificial neural networks
Aktas, Elcin; EROĞLU, HAKAN; Kockan, Umit; ÖNER, LEVENT (2013-08-01)
The purpose of this study was to apply the optimization method incorporating artificial neural network (ANN) using pH-independent release of weakly basic drug, carvedilol from HPMC-based matrix formulation. Because of weakly basic nature of carvedilol, drug shows pH-dependent solubility. The enteric polymer EUDRAGIT L100 was added formulations to overcome pH-dependent solubility of carvedilol. Effects of the Hydroxypropylmethyl cellulose (HPMC) K4M and EUDRAGIT L100 amount on drug release were investigated....
Synthesis of bistriphenylamine- and benzodithiophene-based random conjugated polymers for organic photovoltaic applications
CETIN, Asli; ISTANBULLUOGLU, Cagla; HACIOGLU, Serife Ozdemir; CEVHER, ŞEVKİ CAN; Toppare, Levent Kamil; Çırpan, Ali (2017-11-15)
In this study, donor-acceptor random polymers containing benzotriazole acceptor and bistriphenylamine and benzodithiophene donors, P1 and P2, were successfully synthesized by Stille coupling polymerization. The effect of bistriphenylamine moiety and thiophene -conjugated linker on electrochemical, spectroelectrochemical, and optical behaviors of the polymers were investigated. Optoelectronic properties and photovoltaic performance of the polymers were examined under the illumination of AM 1.5G, 100 mWcm(-2)...
STATISTICAL APPROACH FOR DETERMINING BREAKDOWN VOLTAGE OF GAS-INSULATED CABLES
YILDIRIM, F; KORASLI, C (1992-12-01)
Several goodness-of-fit test procedures were applied to dc-breakdown conditioning test results, obtained in SF6 at 0.4 MPa in concentric-coaxial systems, and to other published data to determine whether the three-parameter Weibull distribution is the only match. The three-parameter Weibull distribution was found to be the best suited among other probabilistic exponential distributions representing the area-dependent statistical characteristics of compressed-gas insulated systems. Parameters of the three-par...
Citation Formats
T. Doğan, M. Gokce, and K. ÖZTÜRK, “Genotoxicity of potent antiviral 1-[(2-aminophenyl)thio]-1-phenyl-2-nitrobutane derivatives designed as drug agents,” TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, pp. 328–335, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/49165.