Alu insertion polymorphisms in Anatolian Turks

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2003

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Dinç, Havva

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In the present study; ten autosomal human-specific Alu insertion polymorphisms; ACE, APO, A25, B65, D1, FXIIIB, HS4.32, HS4.69, PV92 and TPA25 were analyzed in approximately 100 unrelated individuals from Anatolia. Alu insertion polymorphisms offer several advantages over other nuclear DNA polymorphisms for human evolution studies. The frequencies of the ten biallelic Alu insertions in Anatolians were calculated and all systems were found to be in Hardy-Weinberg equilibrium (p>0.05). By combining the results of this study with results of previous studies done on worldwide populations, the genetic distance (Nei̕s DA) between each pair of populations was calculated and neighbor joining trees were constructed. In general, geographically closer populations were found to be also genetically similar. Principal component analysis (PCA) was performed and Anatolia was found to be in the European cluster. As a result of PCA; it was concluded that FXIIIB, PV92 and ACE were the variables contributing the most to the explanation of the variation between the populations. Additionally; canonical variates analysis (CVA) concluded that the most discriminative markers for the groups of populations were PV92, D1, ACE and HS4.32. Pair-wise Fst values were also calculated between Anatolians and some of the populations for which the data was available. It was concluded that, Anatolians have non-significant pair-wise Fst values with Swiss and French Acadian populations. Lastly, heterozygosity vs. distance from centroid graph was constructed and it was found that Anatolians and India-Hindu had exactly the expected heterozygosity value predicted by the model of Harpending and Ward (1982).

Subject Keywords

Alu insertion polymorphisms, Anatolia, Neighbor joining tree, Principal Component Analysis (PCA), Discriminant function analysis, Fst, Heterozygosity vs. distance from centroid

URI

http://etd.lib.metu.edu.tr/upload/1169929/index.pdf
https://hdl.handle.net/11511/13598

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

H. Dinç, “Alu insertion polymorphisms in Anatolian Turks,” M.S. - Master of Science, Middle East Technical University, 2003.