Alu insertion polymorphisms in Anatolian Turks

Download

index.pdf

Date

2003

Author

Dinç, Havva

Metadata

Show full item record

Item Usage Stats

147
views

0
downloads

In the present study; ten autosomal human-specific Alu insertion polymorphisms; ACE, APO, A25, B65, D1, FXIIIB, HS4.32, HS4.69, PV92 and TPA25 were analyzed in approximately 100 unrelated individuals from Anatolia. Alu insertion polymorphisms offer several advantages over other nuclear DNA polymorphisms for human evolution studies. The frequencies of the ten biallelic Alu insertions in Anatolians were calculated and all systems were found to be in Hardy-Weinberg equilibrium (p>0.05). By combining the results of this study with results of previous studies done on worldwide populations, the genetic distance (Nei̕s DA) between each pair of populations was calculated and neighbor joining trees were constructed. In general, geographically closer populations were found to be also genetically similar. Principal component analysis (PCA) was performed and Anatolia was found to be in the European cluster. As a result of PCA; it was concluded that FXIIIB, PV92 and ACE were the variables contributing the most to the explanation of the variation between the populations. Additionally; canonical variates analysis (CVA) concluded that the most discriminative markers for the groups of populations were PV92, D1, ACE and HS4.32. Pair-wise Fst values were also calculated between Anatolians and some of the populations for which the data was available. It was concluded that, Anatolians have non-significant pair-wise Fst values with Swiss and French Acadian populations. Lastly, heterozygosity vs. distance from centroid graph was constructed and it was found that Anatolians and India-Hindu had exactly the expected heterozygosity value predicted by the model of Harpending and Ward (1982).

Subject Keywords

Alu insertion polymorphisms, Anatolia, Neighbor joining tree, Principal Component Analysis (PCA), Discriminant function analysis, Fst, Heterozygosity vs. distance from centroid

URI

http://etd.lib.metu.edu.tr/upload/1169929/index.pdf
https://hdl.handle.net/11511/13598

Collections

Graduate School of Natural and Applied Sciences, Thesis

Suggestions

OpenMETU
Core

Indigo dyeing wastewater reclamation by membrane-based filtration and coagulation processes Unlu, M.; Yukseler, H.; Yetiş, Ülkü (Elsevier BV, 2009-05-15) In the present study. the possibility to reuse the indigo dyeing rinsing wastewater originating from a denim textile mill was investigated. Coagulation and filtration processes were selected as the pretreatment alternatives and applied to dyeing wastewater samples. Both physicochemical pretreatment alternatives and nanofiltration technique were optimized to produce an effluent satisfying the reuse criteria for the textile industry. The results showed that coagulation is not all effective and efficient pretr...
Powder metallurgy of high density W-Ni-Cu alloys Çalışkan, Necmettin Kaan; Bor, Şakir; Department of Metallurgical and Materials Engineering (2006) In the present study; the effects of the powder metallurgical parameters such as the mixing method, compaction pressure, initial tungsten (W) particle size, composition, sintering temperature and sintering time on the sintering behavior of selected high density W-Ni-Cu alloys were investigated. The alloys were produced through conventional powder metallurgy route of mixing, cold compaction and sintering. The total solute (Ni-Cu) content in the produced alloys was kept constant at 10 wt%, while the copper co...
Preparation and characterization of supported PES membranes TOPUZ, BERNA; Yılmaz, Levent; Kalıpçılar, Halil (Journal of the Faculty of Engineering and Architecture of Gazi University, 2019-01-01) In the present study. polyethersulfone (PES) membranes on a macroporous alumina support was prepared by solvent-deposition method to separate H-2/CH4 mixture. The membrane solution viscosities were determined in order to understand the effect of PES concentration on the formation of selective membranes over a support. Supported PES membranes were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and single gas permeability measurements of H-2 and CH4. The membrane casting solution...
Lise Öğrencilerinin Fizik Başarılarına Etki Eden Öğretmen Nitelikleri ile İlgili Algıları Korur, Fikret; Eryılmaz, Ali (Gazi Üniversitesi , 2009-03-01) Bu çalışmanın amacı öğrencilerin fizik başarısını etkileyen öğretmen niteliklerini ve bu niteliklerin öğrencinin fizik başarısına etkilerini araştırmak ve bunların bazı değişkenlerle ilişkili olup olmadığını araştırmaktır. Bu çalışma kapsamında, Türkiye’deki 3 bölgede ve her bölgeden 3 ilde, 9. sınıf seviyesinden 11. sınıf seviyesine kadar toplam 2177 devlet lisesi öğrencisi bulunmaktadır. Öğrencilerden toplanan veriler optik okuyucu yardımıyla bilgisayara girilmiş ve bütün betimsel istatistikleri, geçerlil...
Intergroup relations in a changing political context: the case of veiled and unveiled university students in Turkey Hortacsu, N (Wiley, 2000-09-01) The present study investigated (a) the underlying dimensions of different measures related to identification , categorization, ingroup, bias and contact conditions, and (b) relations between two groups related to an important social controversy over time. Questionnaires were administered to veiled (minority) and unveiled (majority) Turkish female university students during the fall of 1996 and the spring of 1998. Results of factor analysis revealed three factors, namely: tolerance, including percieved outgr...

Citation Formats

H. Dinç, “Alu insertion polymorphisms in Anatolian Turks,” M.S. - Master of Science, Middle East Technical University, 2003.