Biochemical monitoring of toxic and carcinogenic organic pollutants along the İzmir Bay after the great canal project and possible health effects

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2004

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Boyuneğmez, Tuğba

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The induction of hepatic cytochrome P4501A1 and its monooxygenase activity 7-ethoxyresorufin O- deethylase, (EROD) in fish by PAHs, PCBs and dioxins has been suggested as an early warning system أmost sensitive biochemical responseؤ for assessing environmental contamination conditions. In this study, the degree of induction of cytochrome P4501A1 protein as determined immunochemically and CYP1A1 associated EROD activity in fish were utilized as biomarkers of exposure to PAHs, PCBs and related organic pollutants along the Izmir Bay on the Aegean Sea Coast after the Great Canal Project. Three different fish species were used throughout this study, namely leaping mullet (Liza saliens), annular seabream (Diplodus annularis) and common sole (Solea vulgaris) which were representatives of pelagic, benthopelagic and benthic fish, respectively. Fish were sampled in November 2002 and October 2003 from different sites of the Bay. The mullet caught from Harbor, Üçkuyular port site, and Pasaport region displayed highly elevated EROD activities which were 2258±840 (n=15), 2011±490 (n=4), 1813±287 (n=11) pmole /min/mg protein, respectively and were 104, 80 and 79 fold higher than that of fish obtained from the reference point (25±9 pmole/min/mg protein; n=4). Mullet caught along the pollutant gradient at three other sites (Hekim Island, Inciralti, and Zeytinalani) exhibited less but highly significant induced EROD activity. EROD activities of common sole sampled from Foça open sites (107±20 pmol/min/mg protein, n=5) and site16A (80±12 pmol/min/mg protein, n=9) were found to be very low and the latter was accepted as reference site. The highest EROD activity were seen in fish captured from Inciralti which was about 6.3 times higher than those obtained from reference site. Common sole caught from the mouth of Gediz River and Hekim Island exhibited also highly elevated EROD

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General Biology.

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http://etd.lib.metu.edu.tr/upload/12604746/index.pdf
https://hdl.handle.net/11511/14032

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

T. Boyuneğmez, “Biochemical monitoring of toxic and carcinogenic organic pollutants along the İzmir Bay after the great canal project and possible health effects,” M.S. - Master of Science, Middle East Technical University, 2004.