Controlling discrete genetic regulatory networks

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2005
Abul, Osman
Genetic regulatory networks can model dynamics of cells. They also allow for studying the effect of internal or external interventions. Selectively applying interventions towards a certain objective is known as controlling network dynamics. In this thesis work, the issue of how the external interventions af fect the network is studied. The effects are determined using differential gene expression analysis. The differential gene expression problem is further studied to improve the power of the given method. Control problem for dynamic discrete regulatory networks is formulated. This also addresses the needs for various control strategies, e.g., finite horizon, infinite horizon, and various accounting of state and intervention costs. Control schemes for small to large networks are proposed and experimented. A case study is provided to show how the proposals are exploited; also given is the need for and effectiveness of various control schemes.

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Citation Formats
O. Abul, “Controlling discrete genetic regulatory networks,” Ph.D. - Doctoral Program, Middle East Technical University, 2005.