Chemoenzymatic synthesis of 2-ethyl-5-hydroxy-3- methoxy-cyclopent-2-enone

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2005

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Dalfidan, Çağla

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Chiral hydroxylated cyclopentane derivatives are important precursors for biologically active compounds. Synthesis of these types of compounds in optically pure form found increased interest in pharmaceutical chemistry. 2-ethyl-cyclopentane-1.3-dione was acetoxylated using manganese III acetate at preferred positions. Enzyme catalyzed enantioselective hydrolysis or enantioselective acetoxylation of hydrolyzed acetoxy derivatives gives the corresponding hydroxylated diketones in optically pure form.

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Chemistry.

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http://etd.lib.metu.edu.tr/upload/12606916/index.pdf
https://hdl.handle.net/11511/15544

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

Ç. Dalfidan, “Chemoenzymatic synthesis of 2-ethyl-5-hydroxy-3- methoxy-cyclopent-2-enone,” M.S. - Master of Science, Middle East Technical University, 2005.