Chemoenzymatic synthesis of 2-ethyl-5-hydroxy-3- methoxy-cyclopent-2-enone

Date

2005

Author

Dalfidan, Çağla

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Chiral hydroxylated cyclopentane derivatives are important precursors for biologically active compounds. Synthesis of these types of compounds in optically pure form found increased interest in pharmaceutical chemistry. 2-ethyl-cyclopentane-1.3-dione was acetoxylated using manganese III acetate at preferred positions. Enzyme catalyzed enantioselective hydrolysis or enantioselective acetoxylation of hydrolyzed acetoxy derivatives gives the corresponding hydroxylated diketones in optically pure form.

Subject Keywords

Chemistry.

URI

http://etd.lib.metu.edu.tr/upload/12606916/index.pdf
https://hdl.handle.net/11511/15544

Collections

Graduate School of Natural and Applied Sciences, Theses