Addition of acyl phosphonates to ethylcyanoformate

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2007

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Reis, Barbaros

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Functionalized cyanophosphates are important starting materials for the synthesis of beta-lactam ring moiety of beta-lactam antibiotics. The cyanophosphates are synthesized starting from easily available acylphosphonate and ethylcyanoformate. Acylphosphonates are synthesized starting from acylchloride and trimethylphosphite. Addition of acylphoshonate to ethylcyanoformate furnishes the cyanophosphate with the quaternary center.

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Chemistry, Organic

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http://etd.lib.metu.edu.tr/upload/2/12609090/index.pdf
https://hdl.handle.net/11511/17380

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

B. Reis, “Addition of acyl phosphonates to ethylcyanoformate,” M.S. - Master of Science, Middle East Technical University, 2007.