Cost-effectiveness analysis of a prospective breast cancer screening program in Turkey

Download

index.pdf

Date

2011

Author

Astım, Engin

Metadata

Show full item record

Item Usage Stats

253
views

74
downloads

Cancer is the second leading cause of death among the world and it has an increasing share among all causes of death. Economical burden of cancer is increasing especially in high and middle-income countries. Leaving cancer in competitive markets would lead to inefficiencies; hence governments should intervene in the market and make public decisions in struggling cancer. Among all cancer types breast cancer has the highest incidence and mortality rates in females. Causes of breast cancer still remains indeterminate and only way to cope with breast cancer are by early diagnoses. Early diagnoses can best be achieved by regular mammography screenings. This study analyzes the possible outcomes of implementing regular breast cancer mammography screening program in Turkey. A simulation model is constructed and run for 10 years, to obtain the costs and benefits of such a screening program. Costs of such a program include the screening costs and costs due to abnormal mammograms. Benefits, on the other hand are reduced treatment costs due to early diagnosis, reduced mortality and morbidity. Simulation model is run for 11 different screening strategies for determining the optimal screening strategy in terms of screening interval and minimum age to screen. The necessary data is obtained from hospital records, Cancer Early Diagnosis and Treatment Center records, IMF, WHO and TUIK databases and literature. Results of the simulation suggest that women over 40 in Turkey should be screened biennially for economical efficiency.

Subject Keywords

Breast, Canser

URI

http://etd.lib.metu.edu.tr/upload/12612806/index.pdf
https://hdl.handle.net/11511/20410

Collections

Graduate School of Social Sciences, Thesis

Suggestions

OpenMETU
Core

Application of image enhancement algorithms to improve the visibility and classification of microcalcifications in mammograms Akbay, Cansu; Gençer, Nevzat Güneri; Gençer, Gülay; Department of Biomedical Engineering (2015) Breast cancer is the second leading cause of cancer deaths for women. Mammography is the most effective technology presently available for breast cancer screening, despite the fact that there are still some limitations of the imaging technique, such as insufficient resolution, low local contrast and noise combined with the subtle nature of the usual radiographic findings. One of the most important radiographic findings associated to the existence of breast cancer is the clustered microcalcifications. Especi...
Contribution of different types of -omic data on personalized diagnosis of cancer Tanıl, Ezgi; Kızılilsoley, Nehir; Nikerel, Emrah (Orta Doğu Teknik Üniversitesi Enformatik Enstitüsü; 2022-10) Cancer is a complex disease which is one of the main causes of death globally. Survival rate of cancer increases if early diagnosis and application of appropriate treatment are available [1,2]. Understanding differential response from one patient to another can aid in drug targeting, understanding disease progression and finding efficient treatment strategies. Tumour cells shown to have altered metabolism and the most commonly defined example is the Warburg effect in which tumour cells shown to use lactic a...
Structural mapping and network analysis of patient-specific mutations in glioblastoma Kaya, Tuğba; Tunçbağ, Nurcan; Doğan, Tunca; Department of Bioinformatics (2018) Cancer is one of the most common cause of death worldwide. It occurs as a result of a collection of somatic deviations from normal state. Therefore, many efforts have been invested to profile mutations in different types of tumors; such as, the Cancer Genome Atlas (TCGA) which deposits multiple omic data for more than 11,000 tumor samples. In this thesis, we present a pipeline which retrieves patient-specific mutation data in Glioblastoma from TCGA, maps these mutations on the protein structures in Protein ...
Statistical estimation applied to electrocardiographic imaging Serinağaoğlu Doğrusöz, Yeşim (2019-05-01) Cardiovascular diseases are among the leading causes of death all over the world. Researchers have been extensively working on methods for early diagnosis and treatment of these diseases, with the goal of decreasing these death tolls. In Electrocardiographic Imaging (ECGI), the electrical activity of the heart is estimated from electrocardiographic measurements obtained from the body surface, using densely distributed electrodes, and a mathematical model of the body. This technique has advantages over class...
Development and investigation of etoposide resistance in MCF-7 Breast cancer cell line Kaplan, Esra; Gündüz, Ufuk; Department of Biology (2010) Failure of chemotherapy in cancer patients because of development of drug resistance is a major problem. Alterations of DNA repair mechanisms and drug targets are among the important resistance mechanisms which are developed against topoisomerase II inhibitors etoposide and doxorubicin. Modifications in the expression levels of mismatch repair (MMR) genes due to resistance to topoisomerase II inhibitors are involved in breast cancer. In this study, etoposide resistant sublines were developed from MCF7 breas...

Citation Formats

E. Astım, “Cost-effectiveness analysis of a prospective breast cancer screening program in Turkey,” M.S. - Master of Science, Middle East Technical University, 2011.