Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Analysis of threshold dynamics of epidemic models in a periodic environment
Download
index.pdf
Date
2013
Author
Evcin, Cansu
Metadata
Show full item record
Item Usage Stats
231
views
110
downloads
Cite This
Threshold dynamics used to control the spread of the disease in infectious disease phenomena has an overwhelming importance and interest in mathematical epidemiology. One of the famous threshold quantity is known to be the basic reproduction ratio. Its formulation as well as computation is the main concern of infectious diseases. The aim of this thesis is to analyze the basic reproduction ratio in both autonomous and periodic systems via defining R0 as the spectral radius of the next generation operator. This thesis presents the vector host model for the diseases Dengue fever and avian influenza. As emerging of the diseases shows periodicity, systems of periodic ordinary differential equations are considered for both types of diseases. Simple implementation of the time-averaged systems gives rise to the comparison of these with the periodic systems. Thus, we investigate the occurence of the existence of underestimation or overestimation of the basic reproduction ratio in timeaveraged systems.
Subject Keywords
Epidemiology
,
Threshold logic.
,
Periodic functions.
URI
http://etd.lib.metu.edu.tr/upload/12615565/index.pdf
https://hdl.handle.net/11511/22616
Collections
Graduate School of Applied Mathematics, Thesis
Suggestions
OpenMETU
Core
ANALYSIS OF NEUROONCOLOGICAL DATA TO PREDICT SUCCESS OF OPERATION THROUGH CLASSIFICATION
Bagherzadi, Negin; BÖRCEK, ALP ÖZGÜN; TOKDEMİR, GÜL; ÇAĞILTAY, NERGİZ; MARAŞ, HADİ HAKAN (2016-10-05)
Data mining algorithms have been applied in various fields of medicine to get insights about diagnosis and treatment of certain diseases. This gives rise to more research on personalized medicine as patient data can be utilized to predict outcomes of certain treatment procedures. Accordingly, this study aims to create a model to provide decision support for surgeons in Neurooncology surgery. For this purpose, we have analyzed clinical pathology records of Neurooncology patients through various classificatio...
Evaluation of methylation profiles of an epidermal growth factor receptor gene in a head and neck squamous cell carcinoma patient group
Mutlu, M.; Mutlu, Pelin; Azarkan, S.; Baylr, Ö.; Öcal, B.; Saylam, G.; KORKMAZ, MEHMET HAKAN (2021-03-23)
Upregulation of the epidermal growth factor receptor (EGFR) gene has shown an important impact on the development of head and neck cancers due to its important regulation role on multiple cell signaling pathways. The aim of this study was to investigate the methylation pattern of the promoter region of the EGFR gene between head and neck squamous cell carcinoma (HNSCC) patients and a control group. Forty-seven unrelated HNSCC patients, clinically diagnosed at the Department of Otorhinolaryngology, Dlşkapl Y...
Differential immune activation following encapsulation of immunostimulatory CpG oligodeoxynucleotide in nanoliposomes.
Erikçi, E; Gürsel, Mayda; Gürsel, I (2011-02-01)
The immunogenicity of a vaccine formulation is closely related to the effective internalization by the innate immune cells that provide prolonged and simultaneous delivery of antigen and adjuvant to relevant antigen presenting cells. Endosome associated TLR9 recognizes microbial unmethylated CpG DNA. Clinical applications of TLR9 ligands are significantly hampered due to their pre-mature in vivo digestion and rapid clearance. Liposome encapsulation is a powerful tool to increase in vivo stability as well as...
RNA-biology ruling cancer progression? Focus on 3 ' UTRs and splicing
Erson Bensan, Ayşe Elif (Springer Science and Business Media LLC, 2020-09-01)
The protein-coding regions of mRNAs have the information to make proteins and hence have been at the center of attention for understanding altered protein functions in disease states, including cancer. Indeed, the discovery of genomic alterations and driver mutations that change protein levels and/or activity has been pivotal in our understanding of cancer biology. However, to better understand complex molecular mechanisms that are deregulated in cancers, we also need to look at non-coding parts of mRNAs, i...
A test for detecting etiologic heterogeneity in epidemiological studies
Karagulle, S.; Kalaylıoğlu Akyıldız, Zeynep Işıl (2016-02-17)
Current statistical methods for analyzing epidemiological data with disease subtype information allow us to acquire knowledge not only for risk factor-disease subtype association but also, on a more profound account, heterogeneity in these associations by multiple disease characteristics (so-called etiologic heterogeneity of the disease). Current interest, particularly in cancer epidemiology, lies in obtaining a valid p-value for testing the hypothesis whether a particular cancer is etiologically heterogene...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
C. Evcin, “Analysis of threshold dynamics of epidemic models in a periodic environment,” M.S. - Master of Science, Middle East Technical University, 2013.