Novel supramolecular organocatalyst for asymmetric aldol reactions

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2013
Demircan, Ezgi
The proline–calix[4]arene thiourea host–guest complex catalyzed intermolecular aldol reaction of aromatic aldehydes with cyclohexanone is developed. The anti-configured products were obtained in good yields and high enantioselectivities. The reaction is proposed to work via modified Houk–List model, where the carboxylate part of the proline constitutes a supramolecular system with the thiourea. The outcome of the study indicates the influence of the calix[4]arene thiourea on the reactivity and selectivity in a non-polar reaction medium, even in the presence of water at moderate temperatures.

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Citation Formats
E. Demircan, “Novel supramolecular organocatalyst for asymmetric aldol reactions,” M.S. - Master of Science, Middle East Technical University, 2013.