Stochastic simulations of biological networks under impulses

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2016

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Yazıcı, Müge

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The impulses are one of the sources of fluctuations which lead to the sharp changes in the biochemical systems such as the changes in epidemic and population models. In this study, as the novelty, we implement these effects in exact stochastic simulation algorithms, namely, the Gillespie method and the first reaction method, by changing the chemical master equations (CME) with impulses. Hereby in the extension of these approaches with impulses, we consider different scenarios such as the sudden decrease of the number of molecules. Finally, we evaluate each of these alternatives under small and realistically large biochemical systems.

Subject Keywords

Biometry., Algorithms., Biomathematics., Stochastic processes

URI

http://etd.lib.metu.edu.tr/upload/12619937/index.pdf
https://hdl.handle.net/11511/25614

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

M. Yazıcı, “Stochastic simulations of biological networks under impulses,” M.S. - Master of Science, Middle East Technical University, 2016.