Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Microstructural, biological and mechanical investigations of hydroxyapatite-β-tricalcium phosphate composites doped with strontium and fluoride
Download
index.pdf
Date
2016
Author
Pourreza, Elmira
Metadata
Show full item record
Item Usage Stats
322
views
137
downloads
Cite This
The aim of this study was to investigate the microstructure, mechanical and biological properties of biphasic hydroxyapatite--Tricalcium phosphate (HT) and HT substituted with constant fluoride (F−) and varying strontium (Sr2+) amounts. All the samples were synthesized via precipitation method and sintered at 1100°C for 1 h. It was observed that the relative density of the sintered strontium and fluoride doped HT slightly increased. For microstructural analysis, X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) examinations were performed. Remarkable amounts of β-TCP and CaO phases were detected in XRD analysis which could be due to the Ca/P ratio less than 1.67. Lattice parameters increased due to substitutions of ions. In SEM analysis, smaller grains were observed for HT doped with ions. In FTIR analysis, the characteristic bands of HA and -TCP were exhibited. Increased Sr2+ ion contents resulted in increased microhardness values. The highest microhardness value was obtained for the HT doped with 5%Sr2+ and 1%F−. In order to evaluate the cytocompatibility of doped HT, in vitro cytotoxicity tests were performed using Saos-2 cells. Higher initial cell attachment was observed on Sr2+and F− doped HT discs than observed on pure HT.SEM analysis was conducted to examine the morphology of the cells on the surface of the samples. And it was observed that the surface of all discs was covered with cell layers showing perfect cell-material interaction. HT doped with 5%Sr2+ and 1%F− had the optimum structural, mechanical and biocompatibility properties and can be suggested as a good biomaterial for biomedical applications.
Subject Keywords
Hydroxyapatite.
,
Strontium.
,
Fluorides.
,
Phosphates.
,
Biocompatibility.
URI
http://etd.lib.metu.edu.tr/upload/12620364/index.pdf
https://hdl.handle.net/11511/26028
Collections
Graduate School of Natural and Applied Sciences, Thesis
Suggestions
OpenMETU
Core
Nano calcium phosphates doped with titanium and fluoride ions: sinterability and stability of phases
Güngör Geridönmez, Serap; Evis, Zafer; Department of Engineering Sciences (2012)
The purpose of this study was to synthesize calcium phosphates doped with titanium and fluoride ions in different combinations. Pure and doped calcium phosphates were synthesized by a precipitation method. The synthesized materials were sintered at 1100ºC and 1300ºC for 1h. The ceramics were characterized by density measurements to determine the effect of sintering temperature. Presence of phases and bonds were characterized by XRD diffraction and FTIR spectroscopy. Grain sizes of the samples were obtained ...
Catalytic oxidation of nitrogen containing compounds for nitrogen determination
Karakaş, Gürkan (2019-02-15)
The high temperature catalytic oxidation (HTCO) performance of Al2O3 supported Pt, Cu, Cu-Ce and Fe catalysts were systematically studied with a perspective of selective oxidation of nitrogenous compounds to nitric oxide for quantitative determination of bound nitrogen. The catalyst samples were prepared via impregnation and characterized by XRD and BET. In addition, temperature programmed reaction experiments with acetonitrile and oxygen were conducted to evaluate the catalytic activity and selectivity tow...
Microstructure, microhardness, and biocompatibility characteristics of yttrium hydroxyapatite doped with fluoride
Toker, S. M.; Tezcaner, Ayşen; Evis, Zafer (Wiley, 2011-02-01)
The current study focused on doping of hydroxyapatite (HA) with constant yttrium (Y3+) and varying fluoride (F-) compositions to investigate its microstructure, microhardness, and biocompatibility. HA was synthesized by precipitation method and sintered at 1100 degrees C for 1 h. Y3+ and F- ion dopings resulted in changes in densities. In x-ray diffraction analysis, no secondary phase formation was observed. Lattice parameters decreased upon ion substitutions. Scanning electron microscopy (SEM) results show...
Microstructural evolution and room-temperature mechanical properties of as-cast and heat-treated Fe50Al50-nNbn alloys (n=1, 3, 5, 7, and 9 at%)
Yıldırım, Mehmet; Akdeniz, Mahmut Vedat; Mehrabov, Amdulla (2016-05-10)
The microstructural evolution and room-temperature mechanical properties of Fe50Al50-nNbn alloys (n=1, 3, 5, 7, and 9 at%) were investigated after solidification and subsequent heat treatment. For all the compositions, the (Fe, Al)(2)Nb Laves phase formed because of the incomplete solid solubility of Nb in the Fe-Al-based phases and tended to develop an eutectic mixture with the Fe-Al-based phase. According to the results of EDS analysis and microstructural investigations, the Nb concentration of the eutect...
Mechanistic insights into the reactive radicals-assisted degradation of sulfamethoxazole via calcium peroxide activation by manganese-incorporated iron oxide-graphene nanocomposite: Formation of radicals and degradation pathway
Amina, Amina; Si, Xiongyuan; Wu, Kang; Si, Youbin; Yousaf, Balal (2020-03-01)
In this study, fabrication of manganese-incorporated iron oxide-graphene nanocomposite (rGO-FMBO) was reported for the efficient activation of CaO2 and generation of reactive radicals for the degradation of sulfamethoxazole (SMX). The effects of different systems, catalyst dosage, oxidant dosage, different pH and different reaction time on the degradation of SMX by rGO-APTMS-FMBO/CaO2 as well as the production of free radicals were also studied. Electron paramagnetic resonance (EPR) technique was used to de...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
E. Pourreza, “Microstructural, biological and mechanical investigations of hydroxyapatite-β-tricalcium phosphate composites doped with strontium and fluoride,” M.S. - Master of Science, Middle East Technical University, 2016.