A Hierarchical representation and decoding of fMRI data by partitioning a brain network

Moğultay, Hazal
In this study, we propose a hierarchical network representation of human brain extracted from fMRI data. This representation consists of two levels. In the first level, we form a network among the voxels, smallest building block of fMRI data. In the second level, we define a set of supervoxels by partitioning the first level network into a set of subgraphs, which are assu med to represent homogeneous brain regions with respect to a predefined criteria. For this purpose, we develop a novel brain parcellation algorithm, called BrainParcel. As current literature tends to represent human brain as a graph, BrainParcel adopts this approach. The suggested algorithm partitions a brain network, called mesh network using a graph partitioning method. The supervoxels obtained at the output of BrainParcel form partitions of brain as an alternative to anatomical regions (AAL). Compared to AAL, supervoxels gather the linearly dependent voxels. As the next step, we form a mesh network among the supervoxels. Therefore, we represent fMRI data by two networks of different granularity. The first network is at voxel level, whereas the second is at supervoxel level. In order to test the representation power of this two level network, we suggest an ensemble learning architecture, called Cognitive Learner. The suggested ensemble learning method is used in brain decoding problem, where we classified the cognitive states. The results applied on an object recognition problem show that the suggested BrainParcel algorithm together with Cognitive Learner has a better representation power on brain decoding in terms of classification accuracy. 


An Information theoretic representation of brain connectivity for cognitive state classification using functional magnetic resonance imaging
Önal, Itır; Yarman Vural, Fatoş Tunay; Department of Computer Engineering (2013)
In this study, a new method for analyzing and representing the discriminative information, distributed in functional Magnetic Resonance Imaging (fMRI) data, is proposed. For this purpose, a local mesh with varying size is formed around each voxel, called the seed voxel. The relationships among each seed voxel and its neighbors are estimated using a linear regression equation by minimizing the expectation of the squared error. This squared error coming from linear regression is used to calculate various info...
Velioglu, Burak; Aksan, Emre; Onal, Itir; Firat, Orhan; Ozay, Mete; Yarman Vural, Fatoş Tunay (2014-08-20)
In this study, we propose a new approach to construct a two-level functional brain network. The nodes of the first-level network are the voxels of the functional Magnetic Resonance Images (tMRI) recorded during an object recognition task. The nodes of the network at the second-level are the anatomic regions of the brain. The arcs of the first level are estimated by a linear regression equation for the meshes formed around each voxel. Neighbors of each voxel are determined by using a functional similarity me...
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Mojtahedi, Sina; Halıcı, Uğur; Çiçek, Metehan; Department of Biomedical Engineering (2013)
In neuroscience and biomedical engineering fields, one of the most important issues nowadays is finding a relationship between different brain regions when it is stimulated. Connectivity is an important research area in neuroscience which tries to determine the relationship between different brain region when the brain is stimulated externally or internally. Three main type of connectivity are discussed in this field: Anatomical, Functional and Effective connectivity. Importance of effective connectivity is...
An Information Theoretic Approach to Classify Cognitive States Using fMRI
Onal, Itir; Ozay, Mete; Firat, Orhan; GİLLAM, İLKE; Yarman Vural, Fatoş Tunay (2013-11-13)
In this study, an information theoretic approach is proposed to model brain connectivity during a cognitive processing task, measured by functional Magnetic Resonance Imaging (fMRI). For this purpose, a local mesh of varying size is formed around each voxel. The arc weights of each mesh are estimated using a linear regression model by minimizing the squared error. Then, the optimal mesh size for each sample, that represents the information distribution in the brain, is estimated by minimizing various inform...
Representation of human brain by mesh networks
Önal Ertuğrul, Itır; Yarman Vural, Fatoş Tunay; Department of Computer Engineering (2017)
In this thesis, we propose novel representations to extract discriminative information in functional Magnetic Resonance Imaging (fMRI) data for cognitive state and gender classification. First, we model the local relationship among a set of fMRI time series within a neighborhood by considering temporal information obtained from all measurements in time series. The estimated local relationships, called Mesh Arc Descriptors (MADs), are employed to represent information in fMRI data. Second, we adapt encoding ...
Citation Formats
H. Moğultay, “A Hierarchical representation and decoding of fMRI data by partitioning a brain network,” M.S. - Master of Science, Middle East Technical University, 2017.