Synthesis of carborane derivatives for characterization of carbocations

Download
2019
Doğan, Sevban
Weakly coordinating anions are extremely versatile species for capturing and characterizing cationic intermediates. Among these anions, carboranes and some boranes are known to be the most weakly coordinating anions. In this thesis, the carboranes and boranes were synthesized in order to capture and characterize unusual carbocations. B11H14-was synthesized from NaBH4. Undecaborate was converted to B10H14 by oxidation and extrusion of one boron vertex. The B10H14 was successfully converted to ortho-carborane. B11H14 -was treated with I2, and then B12H12 2-was synthesized. Dodecaborane and CB11H12 -were methylated on boron vertex to get B12Me12 2-and HCB11Me11 -. The methylated boranes and carborane cages are more hydrophobic and weakly coordinating anions.

Suggestions

Synthesis and in vitro studies of selenophene containing BODIPY derivatives as mitochondria targeted photodynamic therapy agents
Karaman, Osman; Günbaş, Emrullah Görkem; Department of Chemistry (2019)
Weakly coordinating anions are extremely versatile species for capturing and characterizing cationic intermediates. Among these anions, carboranes and some boranes are known to be the most weakly coordinating anions. In this thesis, the carboranes and boranes were synthesized in order to capture and characterize unusual carbocations. B11H14-was synthesized from NaBH4. Undecaborate was converted to B10H14 by oxidation and extrusion of one boron vertex. The B10H14 was successfully converted to ortho-carborane...
ANALYSES OF ECOSYSTEM-PRIMARY PRODUCTION INTERACTIONS IN THE NORTHERN LEVANTINE BASIN
Yilmaz, Elif; Salihoğlu, Barış; Department of Oceanography (2016-10-12)
Three areas of different ecosystem characteristics in the Northern Levantine Basin is compared using a 1-D multicomponent lower trophic level ecosystem model developed by SALIHOĞLU, B. et al. (2009) (NAGEM). Main focus was to analyze and compare the carrying capacity (PP) and regulatory mechanisms of the nutrients on lower trophic levels. 26 years’ of historical data obtained from METU-IMS data inventory and CORIOLIS was used to form a climatology, to introduce boundary conditions to the model as well as to...
Analysis of acyl CoA ester intermediates of the mevalonate pathway in Saccharomyces cerevisiae.
Şeker, Tamay; Nielsen, J (Springer Science and Business Media LLC, 2005-04-01)
The mevalonate pathway plays an important role in providing the cell with a number of essential precursors for the synthesis of biomass constituents. With respect to their chemical structure, the metabolites of this pathway can be divided into two groups: acyl esters [acetoacetyl CoA, acetyl CoA, hydroxymethylglutaryl (HMG) CoA] and phosphorylated metabolites (isopentenyl pyrophosphate, dimethylallyl pyrophosphate, geranyl pyrophosphate, farnesyl pyrophosphate). In this study, we developed a method for the ...
Determination of metabolic bottlenecks using reaction engineering principles in serine alkaline protease production by recombinant bacillus sp.
Telli, İlkin Ece; Çalık, Pınar; Department of Chemical Engineering (2004)
In this study, firstly, bioprocess characteristics for Serine Alkaline Protease (SAP) production, using recombinant Bacillus subtilis carrying pHV1431::subC, were examined. The cell concentration, substrate concentration, SAP activity and SAP synthesis rate profiles demonstrated that the system reaches to a steady state in terms of cell growth and SAP synthesis between t=15-25 h, therefore, this time interval is appropriate to employ both metabolic flux analysis and metabolic control analysis, which apply s...
Molecular cloning and co-expression of Thermoplasma volcanium proteasome subunit genes
Kocabıyık, Semra; Zwickl, Peter; Ozdogan, Seda (Elsevier BV, 2010-10-01)
In this study we describe, the construction of a co-expression vector allowing simultaneous production of Thermoplasma volcanium 20S proteasome alpha- and beta-subunits in Escherichia coli. This heterologous expression system provided high level production of fully active 205 proteasome that can be purified easily by using a conventional two-step chromatographic technique. The recombinant proteasome was purified to homogeneity 12-fold with a specific activity of 26.5 U/mg. Sodium dodecyl sulfate-polyacrylam...
Citation Formats
S. Doğan, “Synthesis of carborane derivatives for characterization of carbocations,” M.S. - Master of Science, Middle East Technical University, 2019.