Tuğba Doğan

E-mail
tsomay@metu.edu.tr
Department
Central Laboratory
Scopus Author ID
Web of Science Researcher ID
Design, synthesis, molecular docking and ADME studies of novel indole-thiazolidinedione derivatives and their antineoplastic activity as CDK6 inhibitors
Kışla, Mehmet Murat; Zengin Karadayı, Fikriye; Baran, Sercan; Doğan, Tuğba; Mutlu, Pelin; Ateş-Alagöz, Zeynep (2021-09-01)
Several 5-((5-substituted-1H-indole-3-yl)methylene)-3-(2-oxo-2-(3/4-substituted-phenylethyl)-thiazolidine-2,4-dione derivatives (9–24) were designed and synthesized as CDK6 inhibitors, and their anticancer activity w...
Design, synthesis, molecular docking and ADME studies of novel indole-thiazolidinedione derivatives and their antineoplastic activity as CDK6 inhibitors
Kışla, Mehmet Murat; Zengin Karadayı, Fikriye; Baran, Sercan; Doğan, Tuğba; Mutlu, Pelin; Ateş-Alagöz, Zeynep (2021-09-01)
Several 5-((5-substituted-1H-indole-3-yl)methylene)-3-(2-oxo-2-(3/4-substituted-phenylethyl)-thiazolidine-2,4-dione derivatives (9–24) were designed and synthesized as CDK6 inhibitors, and their anticancer activity w...
Yhthesis, Antineoplastic Activity And Molecular Docking Studies Of Novel Indole- Thiazolidinedione Derivatives
Kışla, Mehmet Murat; Zengin Karadayı, Fikriye; Doğan, Tuğba; Mutlu, Pelin; Alagöz, Zeynep (2021-06-22)
Introduction: Cyclin-dependent kinase 6 (CDK6) became a valid target for breast cancer therapy over the past decades. Binding of this enzyme to E2F transcription factors eventually controls cell div...
Peptidomic characterization and bioactivity of Protoiurus kraepelini (Scorpiones: Iuridae) venom
Doğan, Tuğba; BİBER, Aysenur; GEREKCİ, Selin; Hüsnügil, Hepşen Hazal; Özen, Can (2018-01-01)
Protoiurus kraepelini is a scorpion species found in parts of Turkey and Greece. In this study, the peptide profile of its venom was determined for the first time. The electrophoretic profile of the crude venom showed a pr...
Bioactivity Of Protoiurus Kraepelini Scorpione Iuridae Venom
Doğan, Tuğba; Selin, Gerekçi; Hazal, Hüsnügil; İzbırak, Afife; Özen, Can (2016-01-12)
Genotoxicity studies of tetrahydro-naphthalene-benzimidazole/thiazolidinedione as retinoid derivatives
Doğan, Tuğba; Ates-Alagoz, Zeynep; Buyukbingol, Erdem (2015-11-01)
Objective: Mutagenicity is an undesirable side effect of clinically prescribed drugs, thus raises the question of their potential carcinogenicity. Taking into account that nitro compounds are known for their genotoxicity, ...
Characterization of Leiurus abdullahbayrami (Scorpiones: Buthidae) venom: peptide profile, cytotoxicity and antimicrobial activity
ERDES, Efe; Doğan, Tuğba; Cosar, Ilhan; Danisman, Tarik; Kunt, Kadir Bogac; Şeker, Tamay; YUCEL, Meral; Özen, Can (2014-11-03)
Background: Scorpion venoms are rich bioactive peptide libraries that offer promising molecules that may lead to the discovery and development of new drugs. Leiurus abdullahbayrami produces one of the most potent venoms am...
Molecular Characterization and Peptidomic Analysis of Protoiurus kraepelini (Scorpiones:Iuridae) Venom
Doğan, Tuğba; Ergenç, Merve; İğci, Naşit; Özel Demiralp, Fatma Duygu; Kunt, Kadir Boğaç; Özen, Can (2014-09-10)
Leiurus abdullahbayrami (Scorpiones: Buthidae) Venomunun Moleküler Karakterizasyonu ve Peptidomik Analizi
Erdeş, Efe; Doğan, Tuğba; Şeker, Tamay; COŞAR, İLHAN; DANIŞMAN, TARIK; Kunt, Kadir Boğaç; Yücel, Ayşe Meral; Özen, Can (2014-06-23)
Leiurus abdullahbayrami (Scorpiones: Buthidae) Venomunun Moleküler Karakterizasyonu ve Peptidomik Analizi
Erdeş, Efe; Doğan, Tuğba; Şeker, Tamay; Coşar, İlhan; Danışman, Tarık; Kunt, Kadir Boğaç; Özen, Can (2014-06-23)
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