Tuğba Doğan

E-mail

tsomay@metu.edu.tr

Department

Central Laboratory

ORCID

0000-0003-2892-1541

Scopus Author ID

56427787900

Web of Science Researcher ID

AAZ-6712-2021

A Standard Method Verification for Determination of Sugar Content of Commercial Fruit Juices by HPLC Doğan, Tuğba; Şeker, Tamay (2023-07-01) This study aimed to verify the standard test method TS EN 12630 and determine the sugar contents of commercially available fruit juices by high pressure liquid chromatography. A laboratory should verify the standard test m...
Synthesis and investigation of anti-cancer activity of novel substituted alkylsulfonyl 1H- benzo[d]imidazole derivatives in MCF-7 breast cancer cells Abbade, Yemna; Kışla, Mehmet Murat; Al-Kassim Hassan, Mohammed; Doğan, Tuğba; Mutlu, Pelin; Alagöz, Zeynep (2022-11-24)
Design, synthesis, molecular docking and ADME studies of novel indole-thiazolidinedione derivatives and their antineoplastic activity as CDK6 inhibitors Kışla, Mehmet Murat; Zengin Karadayı, Fikriye; Baran, Sercan; Doğan, Tuğba; Mutlu, Pelin; Ateş-Alagöz, Zeynep (2021-09-01) Several 5-((5-substituted-1H-indole-3-yl)methylene)-3-(2-oxo-2-(3/4-substituted-phenylethyl)-thiazolidine-2,4-dione derivatives (9–24) were designed and synthesized as CDK6 inhibitors, and their anticancer activity w...
Design, synthesis, molecular docking and ADME studies of novel indole-thiazolidinedione derivatives and their antineoplastic activity as CDK6 inhibitors Kışla, Mehmet Murat; Zengin Karadayı, Fikriye; Baran, Sercan; Doğan, Tuğba; Mutlu, Pelin; Ateş-Alagöz, Zeynep (2021-09-01) Several 5-((5-substituted-1H-indole-3-yl)methylene)-3-(2-oxo-2-(3/4-substituted-phenylethyl)-thiazolidine-2,4-dione derivatives (9–24) were designed and synthesized as CDK6 inhibitors, and their anticancer activity w...
Yhthesis, Antineoplastic Activity And Molecular Docking Studies Of Novel Indole- Thiazolidinedione Derivatives Kışla, Mehmet Murat; Zengin Karadayı, Fikriye; Doğan, Tuğba; Mutlu, Pelin; Alagöz, Zeynep (2021-06-22) Introduction: Cyclin-dependent kinase 6 (CDK6) became a valid target for breast cancer therapy over the past decades. Binding of this enzyme to E2F transcription factors eventually controls cell div...
Peptidomic characterization and bioactivity of Protoiurus kraepelini (Scorpiones: Iuridae) venom Doğan, Tuğba; BİBER, Aysenur; GEREKCİ, Selin; Hüsnügil, Hepşen Hazal; Özen, Can (2018-01-01) Protoiurus kraepelini is a scorpion species found in parts of Turkey and Greece. In this study, the peptide profile of its venom was determined for the first time. The electrophoretic profile of the crude venom showed a pr...
Bioactivity Of Protoiurus Kraepelini Scorpione Iuridae Venom Doğan, Tuğba; Selin, Gerekçi; Hazal, Hüsnügil; İzbırak, Afife; Özen, Can (2016-01-12)
Genotoxicity studies of tetrahydro-naphthalene-benzimidazole/thiazolidinedione as retinoid derivatives Doğan, Tuğba; Ates-Alagoz, Zeynep; Buyukbingol, Erdem (2015-11-01) Objective: Mutagenicity is an undesirable side effect of clinically prescribed drugs, thus raises the question of their potential carcinogenicity. Taking into account that nitro compounds are known for their genotoxicity, ...
Characterization of Leiurus abdullahbayrami (Scorpiones: Buthidae) venom: peptide profile, cytotoxicity and antimicrobial activity ERDES, Efe; Doğan, Tuğba; Cosar, Ilhan; Danisman, Tarik; Kunt, Kadir Bogac; Şeker, Tamay; YUCEL, Meral; Özen, Can (2014-11-03) Background: Scorpion venoms are rich bioactive peptide libraries that offer promising molecules that may lead to the discovery and development of new drugs. Leiurus abdullahbayrami produces one of the most potent venoms am...
Molecular Characterization and Peptidomic Analysis of Protoiurus kraepelini (Scorpiones:Iuridae) Venom Doğan, Tuğba; Ergenç, Merve; İğci, Naşit; Özel Demiralp, Fatma Duygu; Kunt, Kadir Boğaç; Özen, Can (2014-09-10)

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