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Surface modification of polyurethanes with covalent immobilization of heparin
Date
2007-10-04
Author
AKSOY, AYŞEGÜL
Hasırcı, Vasıf Nejat
Hasırcı, Nesrin
Metadata
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
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Thrombus formation and blood coagulation is a major problem associated with blood contacting products such as catheters, vascular grafts, arteries, artificial hearts and heart valves. An intense research is being conducted towards the synthesis of new hemocompatible materials and modifications of surfaces with biological molecules. In this study, polyurethane (PU) films were synthesized in medical purity from diisocyanate and polyol without using any other ingredients and their surfaces were modified by covalent immobilization of heparin. Two types of heparin, unfractionated (UFH) and low molecular weight heparin (LMWH), were immobilized to investigate their effect on cell adhesion. The surface properties of the modified PUs were examined with ESCA, ATR-FTIR and AFM. ESCA results demonstrated sulfur peaks indicating the presence of heparin and AFM results showed the alteration of surface structure after coating with heparin. Cell adhesion studies were conducted with heparinized whole human blood. The surfaces of the UFH immobilized films resulted in lesser red blood cell adhesion in comparison to LMWH demonstrating strong antithrombogenic activity of the latter.
Subject Keywords
Surface modification
,
Surface modification
,
Polyurethane
,
heparin
,
Hemocompatibility
,
ESCA/XPS
URI
https://hdl.handle.net/11511/29975
DOI
https://doi.org/10.1002/masy.200850918
Collections
Graduate School of Natural and Applied Sciences, Conference / Seminar