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Gene expression analysis of drug-resistant MCF-7 cells: implications for relation to extracellular matrix proteins
Date
2010-02-01
Author
Iseri, Oezlem Darcansoy
Kars, Meltem Demirel
Arpaci, Fikret
Gündüz, Ufuk
Metadata
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Since multidrug resistance is a multifactorial phenomenon, a large-scale expression analysis of drug-resistant cells by using high-density oligonucleotide microarrays may provide information about new candidate genes contributing to resistance. Extracellular matrix (ECM) is responsible for many aspects of proliferation and invasive/metastatic behavior of tumor cells. This study demonstrates alterations in gene expression levels of several ECM components, matrix metalloproteinases (MMPs), adamalysins (ADAMs and ADAMTSs) and tissue inhibitors of metalloproteinases (TIMPs) in paclitaxel, docetaxel, vincristine and doxorubicin-resistant MCF-7 cells.
Subject Keywords
Multidrug resistance
,
cDNA microarray
,
ECM
,
Integrin
,
MMP
,
ADAM
URI
https://hdl.handle.net/11511/30146
Journal
CANCER CHEMOTHERAPY AND PHARMACOLOGY
DOI
https://doi.org/10.1007/s00280-009-1048-z
Collections
Graduate School of Natural and Applied Sciences, Article