CpG DNA: recognition by and activation of monocytes.

Date

2002-07-01

Author

Klinman, DM
Takeshita, F
Gursel, I
Leifer, C
Ishii, KJ
Verthelyi, D
Gürsel, Mayda

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Unmethylated CpG motifs present in bacterial DNA rapidly trigger an innate immune response characterized by the activation of Ig- and cytokine-secreting cells. Synthetic oligonucleotides (ODNs) containing CpG motifs mimic this activity, triggering monocytes to proliferate, secrete and/or differentiate. Analysis of hundreds of novel ODNs led to the identification of two structurally distinct classes of CpG motif that differentially activate human monocytes. ODNs of the "K"-type interact with Toll-like receptor 9 and induce monocytes to proliferate and secrete IL-6. In contrast, "D"-type ODNs trigger monocytes to differentiate into mature dendritic cells.

Subject Keywords

CpG DNA, Activation, Monocytes

URI

https://hdl.handle.net/11511/41363

Journal

Microbes and infection

DOI

https://doi.org/10.1016/s1286-4579(02)01614-3

Collections

Department of Biology, Article

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Citation Formats

D. Klinman et al., “CpG DNA: recognition by and activation of monocytes.,” Microbes and infection, pp. 897–901, 2002, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/41363.