Etoposide resistance in MCF-7 breast cancer cell line is marked by multiple mechanisms

2014-04-01
Alpsoy, Aktan
Yasa, Seda
Gündüz, Ufuk
Purpose: Acquired or intrinsic drug resistance is one of the major handicaps in the success of chemotherapy. Etoposide is a topoisomerase II poison widely used in chemotherapy. Similar to other topoisomerase inhibitors and DNA damaging agents, resistance to etoposide may arise as a result of alterations in target expression and activity, increased drug efflux and alterations in DNA damage response mechanisms. Here, we tested the involvement of such mechanisms in etoposide-resistant MCF-7 breast cancer cells.
Citation Formats
A. Alpsoy, S. Yasa, and U. Gündüz, “Etoposide resistance in MCF-7 breast cancer cell line is marked by multiple mechanisms,” pp. 351–355, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30515.