Etoposide resistance in MCF-7 breast cancer cell line is marked by multiple mechanisms

Date

2014-04-01

Author

Alpsoy, Aktan
Yasa, Seda
Gündüz, Ufuk

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Purpose: Acquired or intrinsic drug resistance is one of the major handicaps in the success of chemotherapy. Etoposide is a topoisomerase II poison widely used in chemotherapy. Similar to other topoisomerase inhibitors and DNA damaging agents, resistance to etoposide may arise as a result of alterations in target expression and activity, increased drug efflux and alterations in DNA damage response mechanisms. Here, we tested the involvement of such mechanisms in etoposide-resistant MCF-7 breast cancer cells.

Subject Keywords

Etoposide, Chemoresistance, Breast cancer

URI

https://hdl.handle.net/11511/30515

Journal

BIOMEDICINE & PHARMACOTHERAPY

DOI

https://doi.org/10.1016/j.biopha.2013.09.007

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

A. Alpsoy, S. Yasa, and U. Gündüz, “Etoposide resistance in MCF-7 breast cancer cell line is marked by multiple mechanisms,” BIOMEDICINE & PHARMACOTHERAPY, pp. 351–355, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30515.