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Expression analysis of TOP2A, MSH2 and MLH1 genes in MCF7 cells at different levels of etoposide resistance
Date
2012-02-01
Author
Kaplan, Esra
Gündüz, Ufuk
Metadata
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Purpose: Development of resistance against anti-cancer drugs is one of the major obstacles of chemotherapy in the treatment of cancer. Etoposide is a topoisomerase II alpha (TOP2A) inhibitor, which is used in the treatment of breast cancer. Alterations in the expression of drug targets or DNA repair genes are among the important resistance mechanisms against TOP2A inhibitors. In this study, expression changes in TOP2A gene and two important mismatch repair (MMR) genes MSH2 and MLH1 were examined in order to understand the relationship between differential expression of these genes and drug resistance against etoposide.
Subject Keywords
Breast cancer
,
Chemotherapy resistance
,
Etoposide
URI
https://hdl.handle.net/11511/31393
Journal
BIOMEDICINE & PHARMACOTHERAPY
DOI
https://doi.org/10.1016/j.biopha.2011.09.002
Collections
Graduate School of Natural and Applied Sciences, Article