Optimization of ethanol-water extraction of lignans from flaxseed

Date

2007-10-01

Author

Zhang, Zhen-Shan
Li, Dong
Wang, Li-Jun
Özkan, Necati
Chen, Xiao Dong
Mao, Zhi-Huai
Yang, Hong-Zhi

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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The optimal conditions for the extraction of lignans from flaxseed were determined. A second-order regression for rotation-orthogonal composite design was used to investigate the effects of three independent variables, namely ethanol concentration (%), extraction temperature (degrees C, and extraction time (h) on the response, the acquired ratio of lignans. The independent variables were coded at five levels and their actual values selected on the basis of results of single-factor experiment. The second-order regression for rotation-orthogonal composite design consisted of 23 experimental points and 9 replications at the central point. Data were analyzed using MATLAB software. The results indicated that acquired ratio of lignans might be beyond 8% at a probability of 95% in the range of ethanol concentration: 56.6-83.4%, extraction time: 26.7-27.9 h, extraction temperature: 38.7-40.1 degrees C. And the optimal extraction conditions were ethanol concentration of 70%, extraction time of 28h and extraction temperature of 40 degrees C according to the analysis of response surface. In this condition, the experimental acquired ratio of lignans was 8.975% (w/w; lignans/defatted flaxseed powder), which is close to the predicted value (9.316%).

Subject Keywords

Flaxseed, Acquired ratio of lignans, Response surface, Optimization

URI

https://hdl.handle.net/11511/30598

Journal

SEPARATION AND PURIFICATION TECHNOLOGY

DOI

https://doi.org/10.1016/j.seppur.2007.03.006

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

Z.-S. Zhang et al., “Optimization of ethanol-water extraction of lignans from flaxseed,” SEPARATION AND PURIFICATION TECHNOLOGY, pp. 17–24, 2007, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30598.