Fungi mediated conversion of benzil to benzoin and hydrobenzoin

Date

2004-08-23

Author

Demir, AS
Hamamcı, Haluk
Ayhan, P
Duygu, AN
Igdir, AC
Capanoglu, D

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An enzyme system of four fungi catalyses the reduction of benzil to benzoin, as well as benzoin to hydrobenzoin. Depending on the pH of the medium, both enantiomers of benzoin can be obtained in good yield and high ee starting from benzil via a reduction, as well as from rac-benzoin via a novel deracemization reaction. Starting from benzil, (R)-, (S)- and rac-benzoin only (R,R)-hydrobenzoin was obtained in high ee and chemical yield.

Subject Keywords

Ligand, Cleavage, Auxiliary, Convenient, Reduction, Aryl aldehydes, Hydroxy ketones, Kinetic resolution, Enantioselective synthesis, Asymmetric dihydroxylation

URI

https://hdl.handle.net/11511/30834

Journal

TETRAHEDRON-ASYMMETRY

DOI

https://doi.org/10.1016/j.tetasy.2004.07.010

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

A. Demir, H. Hamamcı, P. Ayhan, A. Duygu, A. Igdir, and D. Capanoglu, “Fungi mediated conversion of benzil to benzoin and hydrobenzoin,” TETRAHEDRON-ASYMMETRY, pp. 2579–2582, 2004, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30834.