Fungi mediated enantioselective biohydrogenation of benzils to benzoins

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2008

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Demirtaş, Umut

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Benzoin is an important a-hydroxy ketone which can be used as chiral intermediate for the synthesis of several drugs. In this study, it was aimed to synthesize this compound by high stereoslectivity and yield by the use of fungal bioconversions. For this purpose, whole cells of four different Fusarium spp. (F. anguoides, F. roseum, F. solanii, F.bulbigenum) were used for reduction of readily available achiral compound benzil. The reaction conditions were optimized as glucose peptone broth consisting of 30g/L glucose and 10 g/L peptone, inoculum size as 20 mg/L and substrate concentration as 200 mg/L. A complete set of derivatives substituted with electron donating and electron withdrawing groups of the benzils were also reduced to the corresponding benzoin derivatives with the same optimized condition with up to 98% ee.

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http://etd.lib.metu.edu.tr/upload/2/12609232/index.pdf
https://hdl.handle.net/11511/17468

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

U. Demirtaş, “Fungi mediated enantioselective biohydrogenation of benzils to benzoins,” M.S. - Master of Science, Middle East Technical University, 2008.