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Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones

2001-07-30
Demir, AS
Hamamcı, Haluk
Sesenoglu, O
Aydogan, F
Capanoglu, D
Neslihanoglu, R
A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in high enantiomeric excess.