Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones

Date

2001-07-30

Author

Demir, AS
Hamamcı, Haluk
Sesenoglu, O
Aydogan, F
Capanoglu, D
Neslihanoglu, R

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A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in high enantiomeric excess.

Subject Keywords

Alpha-hydroxy ketones, Enantioselective synthesis, Benzoylformate decarboxylase, Antifungals, Derivatives, Resolution, Precursor, Oxidation, Acetoxy, Salts

URI

https://hdl.handle.net/11511/30861

Journal

TETRAHEDRON-ASYMMETRY

DOI

https://doi.org/10.1016/s0957-4166(01)00346-9

Collections

Graduate School of Natural and Applied Sciences, Article

Citation Formats

A. Demir, H. Hamamcı, O. Sesenoglu, F. Aydogan, D. Capanoglu, and R. Neslihanoglu, “Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones,” TETRAHEDRON-ASYMMETRY, vol. 12, no. 13, pp. 1953–1956, 2001, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30861.