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Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones
Date
2001-07-30
Author
Demir, AS
Hamamcı, Haluk
Sesenoglu, O
Aydogan, F
Capanoglu, D
Neslihanoglu, R
Metadata
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This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
.
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A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in high enantiomeric excess.
Subject Keywords
Alpha-hydroxy ketones
,
Enantioselective synthesis
,
Benzoylformate decarboxylase
,
Antifungals
,
Derivatives
,
Resolution
,
Precursor
,
Oxidation
,
Acetoxy
,
Salts
URI
https://hdl.handle.net/11511/30861
Journal
TETRAHEDRON-ASYMMETRY
DOI
https://doi.org/10.1016/s0957-4166(01)00346-9
Collections
Graduate School of Natural and Applied Sciences, Article