Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones

Date

2001-07-30

Author

Demir, AS
Hamamcı, Haluk
Sesenoglu, O
Aydogan, F
Capanoglu, D
Neslihanoglu, R

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A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in high enantiomeric excess.

Subject Keywords

Alpha-hydroxy ketones, Enantioselective synthesis, Benzoylformate decarboxylase, Antifungals, Derivatives, Resolution, Precursor, Oxidation, Acetoxy, Salts

URI

https://hdl.handle.net/11511/30861

Journal

TETRAHEDRON-ASYMMETRY

DOI

https://doi.org/10.1016/s0957-4166(01)00346-9

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

A. Demir, H. Hamamcı, O. Sesenoglu, F. Aydogan, D. Capanoglu, and R. Neslihanoglu, “Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones,” TETRAHEDRON-ASYMMETRY, pp. 1953–1956, 2001, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30861.