Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones

2001-07-30
Demir, AS
Hamamcı, Haluk
Sesenoglu, O
Aydogan, F
Capanoglu, D
Neslihanoglu, R
A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in high enantiomeric excess.

Citation Formats
A. Demir, H. Hamamcı, O. Sesenoglu, F. Aydogan, D. Capanoglu, and R. Neslihanoglu, “Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones,” TETRAHEDRON-ASYMMETRY, vol. 12, no. 13, pp. 1953–1956, 2001, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30861.