Synthesis and biological evaluation of optically active conjugated gamma- and delta-lactone derivatives

2012-09-15
ŞARDAN, Melis
Sezer, Serdar
GUNEL, Aslihan
AKKAYA, MAHİNUR
Tanyeli, Cihangir
An efficient synthesis of racemic and both enantiomeric forms of heteroaryl substituted gamma- and delta-lactone derivatives derived from allyl and homoallyl alcohol backbones has been accomplished via ring closing metathesis reaction. 2-Heteroaryl substituted allyl and homoallyl alcohols have been efficiently resolved through enzymatic method with high ee (97-99%) and known stereochemistry. Antimicrobial and antioxidant activities of target lactones were evaluated.

Citation Formats
M. ŞARDAN, S. Sezer, A. GUNEL, M. AKKAYA, and C. Tanyeli, “Synthesis and biological evaluation of optically active conjugated gamma- and delta-lactone derivatives,” BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, no. 18, pp. 5814–5818, 2012, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/41482.