Synthesis and biological evaluation of optically active conjugated gamma- and delta-lactone derivatives

Date

2012-09-15

Author

ŞARDAN, Melis
Sezer, Serdar
GUNEL, Aslihan
AKKAYA, MAHİNUR
Tanyeli, Cihangir

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An efficient synthesis of racemic and both enantiomeric forms of heteroaryl substituted gamma- and delta-lactone derivatives derived from allyl and homoallyl alcohol backbones has been accomplished via ring closing metathesis reaction. 2-Heteroaryl substituted allyl and homoallyl alcohols have been efficiently resolved through enzymatic method with high ee (97-99%) and known stereochemistry. Antimicrobial and antioxidant activities of target lactones were evaluated.

Subject Keywords

Asymmetric synthesis, Enzymatic resolution, Optically active lactones

URI

https://hdl.handle.net/11511/41482

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

DOI

https://doi.org/10.1016/j.bmcl.2012.07.090

Collections

Department of Chemistry, Article

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Citation Formats

M. ŞARDAN, S. Sezer, A. GUNEL, M. AKKAYA, and C. Tanyeli, “Synthesis and biological evaluation of optically active conjugated gamma- and delta-lactone derivatives,” BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, pp. 5814–5818, 2012, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/41482.