Synthesis and biological evaluation of optically active conjugated gamma- and delta-lactone derivatives

2012-09-15
ŞARDAN, Melis
Sezer, Serdar
GUNEL, Aslihan
AKKAYA, MAHİNUR
Tanyeli, Cihangir
An efficient synthesis of racemic and both enantiomeric forms of heteroaryl substituted gamma- and delta-lactone derivatives derived from allyl and homoallyl alcohol backbones has been accomplished via ring closing metathesis reaction. 2-Heteroaryl substituted allyl and homoallyl alcohols have been efficiently resolved through enzymatic method with high ee (97-99%) and known stereochemistry. Antimicrobial and antioxidant activities of target lactones were evaluated.