PAMAM dendrimer-coated iron oxide nanoparticles: synthesis and characterization of different generations

Date

2013-03-01

Author

Khodadust, Rouhollah
Unsoy, Gozde
Yalcin, Serap
Gunduz, Gungor
Gündüz, Ufuk

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This study focuses on the synthesis and characterization of different generations (G(0)-G(7)) of polyamidoamine (PAMAM) dendrimer-coated magnetic nanoparticles (DcMNPs). In this study, superparamagnetic iron oxide nanoparticles were synthesized by co-precipitation method. The synthesized nanoparticles were modified with aminopropyltrimethoxysilane for dendrimer coating. Aminosilane-modified MNPs were coated with PAMAM dendrimer. The characterization of synthesized nanoparticles was performed by X-ray diffraction, X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), dynamic light scattering, and vibrating sample magnetometry (VSM) analyses. TEM images demonstrated that the DcMNPs have monodisperse size distribution with an average particle diameter of 16 +/- 5 nm. DcMNPs were found to be superparamagnetic through VSM analysis. The synthesis, aminosilane modification, and dendrimer coating of iron oxide nanoparticles were validated by FTIR and XPS analyses. Cellular internalization of nanoparticles was studied by inverted light scattering microscopy, and cytotoxicity was determined by XTT analysis. Results demonstrated that the synthesized DcMNPs, with their functional groups, symmetry perfection, size distribution, improved magnetic properties, and nontoxic characteristics could be suitable nanocarriers for targeted cancer therapy upon loading with various anticancer agents.

Subject Keywords

Iron oxide (Fe3O4), Dendrimer, Magnetic nanoparticle, Cancer therapy

URI

https://hdl.handle.net/11511/30930

Journal

JOURNAL OF NANOPARTICLE RESEARCH

DOI

https://doi.org/10.1007/s11051-013-1488-6

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

R. Khodadust, G. Unsoy, S. Yalcin, G. Gunduz, and U. Gündüz, “PAMAM dendrimer-coated iron oxide nanoparticles: synthesis and characterization of different generations,” JOURNAL OF NANOPARTICLE RESEARCH, pp. 0–0, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30930.