PAMAM dendrimer-coated iron oxide nanoparticles: synthesis and characterization of different generations

Date

2013-03-01

Author

Khodadust, Rouhollah
Unsoy, Gozde
Yalcin, Serap
Gunduz, Gungor
Gündüz, Ufuk

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

195
views

0
downloads

This study focuses on the synthesis and characterization of different generations (G(0)-G(7)) of polyamidoamine (PAMAM) dendrimer-coated magnetic nanoparticles (DcMNPs). In this study, superparamagnetic iron oxide nanoparticles were synthesized by co-precipitation method. The synthesized nanoparticles were modified with aminopropyltrimethoxysilane for dendrimer coating. Aminosilane-modified MNPs were coated with PAMAM dendrimer. The characterization of synthesized nanoparticles was performed by X-ray diffraction, X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), dynamic light scattering, and vibrating sample magnetometry (VSM) analyses. TEM images demonstrated that the DcMNPs have monodisperse size distribution with an average particle diameter of 16 +/- 5 nm. DcMNPs were found to be superparamagnetic through VSM analysis. The synthesis, aminosilane modification, and dendrimer coating of iron oxide nanoparticles were validated by FTIR and XPS analyses. Cellular internalization of nanoparticles was studied by inverted light scattering microscopy, and cytotoxicity was determined by XTT analysis. Results demonstrated that the synthesized DcMNPs, with their functional groups, symmetry perfection, size distribution, improved magnetic properties, and nontoxic characteristics could be suitable nanocarriers for targeted cancer therapy upon loading with various anticancer agents.

Subject Keywords

Iron oxide (Fe3O4), Dendrimer, Magnetic nanoparticle, Cancer therapy

URI

https://hdl.handle.net/11511/30930

Journal

JOURNAL OF NANOPARTICLE RESEARCH

DOI

https://doi.org/10.1007/s11051-013-1488-6

Collections

Graduate School of Natural and Applied Sciences, Article

Suggestions

OpenMETU
Core

PAMAM Dendrimer Coated MNPs for siRNA Delivery and Gene Silencing Unsoy, Gözde; Yalçın Azarkan, Serap; Khodadust, R; Parsiyan, M; Mutlu, P; Bayanbold, H; Gündüz, Ufuk (2014-04-01) In this study, superparamagnetic iron oxide nanoparticles were synthesized by co-precipitation method. The synthesized nanoparticles were modified with aminopropyl-trimethoxysilane for dendrimer coating. Aminosilane-modified MNPs were coated with PAMAM dendrimer. Gene silencing effect of Survivin siRNA loaded nanoparticles (NPs) were studied on Doxorubicin resistant MCF-7 cell lines. Consequently, Survivin siRNA were triggered cell death when delivered by G4 PAMAM dendrimer coated magnetic nanoparticles. Su...
Magnetic Fe3O4-chitosan micro- and nanoparticles for wastewater treatment ŞAHBAZ, DENİZ AKIN; YAKAR, ARZU; Gündüz, Ufuk (2019-08-18) In this study, first, magnetic nanoparticles (MNP) were synthesized using a coprecipitation method and the synthesized particles were characterized using Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), dynamic light scattering (DLS), and vibrating sample magnetometry (VSM). According to DLS and VSM analyses results, it was seen that the size of the MNP was smaller than 10 nm and they exhibited superparamagnetic properties, respectively. Then, magnetic Fe3O4-chitosan micro/n...
Polyinosinic: polycytidylic acid loading onto different generations of PAMAM dendrimer-coated magnetic nanoparticles Khodadust, Rouhollah; Mutlu, Pelin; Yalcin, Serap; Unsoy, Gozde; Gündüz, Ufuk (2013-08-01) Poly (I:C), which is a synthetic double-stranded RNA, have significant toxicity on tumor cells. The immobilization of Poly (I:C) onto nanoparticles is important for the fabrication of targeted delivery systems. In this study, different generations of newly synthesized PAMAM dendron-coated magnetic nanoparticles (DcMNP) which can be targeted to the tumor site under magnetic field were efficiently loaded for the first time with Poly (I:C). Different generations of DcMNPs (G(2), G(3), G(4), G(5), G(6), and G(7...
The Effect of Ultrasonication on the Size and Morphology of Iron Oxide - Chitosan Nano and Microparticles Akin, Deniz; YAKAR, ARZU; Gündüz, Ufuk (2013-04-28) The aim of this study is to synthesize magnetic Fe3O4-chitosan nano and microparticles (Fe3O4-CPs) by suspension cross-linking and ionic gelation methods and investigate the effect of ultrasonication on the size, morphology and magnetic properties. The synthesized particles were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and vibrating sample magnetometry (VSM). The results showed that the ultrasonication decreased the mean particle diameter and enhanced magnetic ...
Synthesis, structural and magnetic characterization of soft magnetic nanocrystalline ternary FeNiCo particles Toparlı, Çiğdem; Gürmen, Sebahattin (2017-02-01) The present study focuses on the synthesis, microstructural and magnetic properties of ternary FeNiCo nanoparticles. Nanocrystalline ternary FeNiCo particles were synthesized via hydrogen reduction assisted ultrasonic spray pyrolysis method in single step. The effect of precursor concentration on the morphology and the size of particles was investigated. The syntheses were performed at 800 degrees C. Structure, morphology and magnetic properties of the as-prepared products were characterized through X-ray d...

Citation Formats

R. Khodadust, G. Unsoy, S. Yalcin, G. Gunduz, and U. Gündüz, “PAMAM dendrimer-coated iron oxide nanoparticles: synthesis and characterization of different generations,” JOURNAL OF NANOPARTICLE RESEARCH, pp. 0–0, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30930.