PAMAM Dendrimer Coated MNPs for siRNA Delivery and Gene Silencing

Date

2014-04-01

Author

Unsoy, Gözde
Yalçın Azarkan, Serap
Khodadust, R
Parsiyan, M
Mutlu, P
Bayanbold, H
Gündüz, Ufuk

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In this study, superparamagnetic iron oxide nanoparticles were synthesized by co-precipitation method. The synthesized nanoparticles were modified with aminopropyl-trimethoxysilane for dendrimer coating. Aminosilane-modified MNPs were coated with PAMAM dendrimer. Gene silencing effect of Survivin siRNA loaded nanoparticles (NPs) were studied on Doxorubicin resistant MCF-7 cell lines. Consequently, Survivin siRNA were triggered cell death when delivered by G4 PAMAM dendrimer coated magnetic nanoparticles. Survivin siRNA loaded G4 MNPs facilitate to overcome drug resistance on Doxorubicin resistant breast cancer cells.

Subject Keywords

PAMAM dendrimer, Magnetic nanoparticle, Resistant MCF-7 cell line

URI

https://hdl.handle.net/11511/80145
https://metu.academia.edu/GozdeUnsoy

Journal

Journal of Cancer Studies and Therapy

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

G. Unsoy et al., “PAMAM Dendrimer Coated MNPs for siRNA Delivery and Gene Silencing,” Journal of Cancer Studies and Therapy, pp. 1–5, 2014, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/80145.