Loading of Gemcitabine on chitosan magnetic nanoparticles increases the anti-cancer efficacy of the drug

2016-08-05
PARSIAN, Maryam
UNSOY, Gozde
Mutlu, Pelin
Yalcin, Serap
Tezcaner, Ayşen
Gündüz, Ufuk
Targeted delivery of anti-cancer drugs increase the efficacy, while decreasing adverse effects. Among various delivery systems, chitosan coated iron oxide nanoparticles (CsMNPs) gained attention with their biocompatibility, biodegradability, low toxicity and targetability under magnetic field. This study aimed to increase the cellular uptake and efficacy of Gemcitabine.
EUROPEAN JOURNAL OF PHARMACOLOGY

Suggestions

Synthesis of Doxorubicin loaded magnetic chitosan nanoparticles for pH responsive targeted drug delivery
ÜNSOY, GÖZDE; Khodadust, Rouhollah; Yalcin, Serap; Mutlu, Pelin; Gündüz, Ufuk (2014-10-01)
Targeted drug delivery is a promising alternative to overcome the limitations of classical chemotherapy. In an ideal targeted drug delivery system carrier nanoparticles would be directed to the tumor tissue and selectively release therapeutic molecules. As a novel approach, chitosan coated magnetic nanoparticles (CS MNPs) maintain a pH dependent drug delivery which provides targeting of drugs to the tumor site under a magnetic field. Among various materials, chitosan has a great importance as a pH sensitive...
Poly (I:C)- and doxorubicin-loaded magnetic dendrimeric nanoparticles affect the apoptosis-related gene expressions in MCF-7 cells
Khodadust, Rouhollah; Alpsoy, Aktan; Ünsoy, Gözde; Gündüz, Ufuk (The Scientific and Technological Research Council of Turkey, 2020-8-19)
Use of nanoparticles as drug carrier vectors has great potential to circumvent the limitations associated with chemotherapy, including drug resistance and destructive side effects. For this purpose, magnetic generation 4 dendrimeric nanoparticles were prepared to carry chemotherapeutic agent doxorubicin (G 4-DOX) and immune modulator polyinosinic:polycytidylic acid [Poly(I:C)]. As previously reported, DOX and Poly(I:C) was loaded onto G 4 nanoparticles (PIC-G 4-DOX). Cellular internalization study using con...
Half generations magnetic PAMAM dendrimers as an effective system for targeted gemcitabine delivery
PARSIAN, MARYAM; Mutlu, Pelin; Yalcin, Serap; Tezcaner, Ayşen; Gündüz, Ufuk (2016-12-30)
Tumor-specific delivery of anticancer drugs by magnetic nanoparticles will maximize the efficacy of the drug and minimize side effects, and reduce systemic toxicity. The magnetic core of these nanoparticles provides an advantage for selective drug targeting as they can be targeted to the tumor site and accumulated in cancer cells by means of an external magnetic field. Magnetic nanoparticles can be coated with Polyamidoamine (PAMAM) dendrimer and loaded with drugs. However, biomedical applications of PAMAM ...
Synthesis and characterization of polymeric magnetic nanoparticles loaded by gemcitabine /
Parsian, Maryam; Gündüz, Ufuk; Tezcaner, Ayşen; Department of Biotechnology (2014)
In this study, different types of magnetic nanoparticles were synthesized for treatment of breast cancer by targeted drug delivery. Polyamidoamine (PAMAM) dendrimer, Chitosan (CS) and Polyhydroxybutyrate (PHB) coated magnetic nanoparticles were prepared and loaded with Gemcitabine. The loading efficiency of drug for various half generations of dendrimer coated magnetic nanoparticles (DcMNPs), Chitosan coated magnetic nanoparticles (CSMNPs) and Polyhydroxybutyrate magnetic nanoparticles (PHB-MNPs) were inves...
Smart Drug Delivery Systems in Cancer Therapy
ÜNSOY, GÖZDE; Gündüz, Ufuk (2018-01-01)
Background: Smart nanocarriers have been designed for tissue-specific targeted drug delivery, sustained or triggered drug release and co-delivery of synergistic drug combinations to develop safer and more efficient therapeutics.
Citation Formats
M. PARSIAN, G. UNSOY, P. Mutlu, S. Yalcin, A. Tezcaner, and U. Gündüz, “Loading of Gemcitabine on chitosan magnetic nanoparticles increases the anti-cancer efficacy of the drug,” EUROPEAN JOURNAL OF PHARMACOLOGY, pp. 121–128, 2016, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31022.