Show/Hide Menu
Hide/Show Apps
Logout
Türkçe
Türkçe
Search
Search
Login
Login
OpenMETU
OpenMETU
About
About
Open Science Policy
Open Science Policy
Open Access Guideline
Open Access Guideline
Postgraduate Thesis Guideline
Postgraduate Thesis Guideline
Communities & Collections
Communities & Collections
Help
Help
Frequently Asked Questions
Frequently Asked Questions
Guides
Guides
Thesis submission
Thesis submission
MS without thesis term project submission
MS without thesis term project submission
Publication submission with DOI
Publication submission with DOI
Publication submission
Publication submission
Supporting Information
Supporting Information
General Information
General Information
Copyright, Embargo and License
Copyright, Embargo and License
Contact us
Contact us
Inclusion of celecoxib in the SBA-15 mesoporous silica: drug loading and release property
Download
index.pdf
Date
2016
Author
Eren, Zeynep Seda
Metadata
Show full item record
Item Usage Stats
322
views
134
downloads
Cite This
Mesoporous silica particles have been used to enhance the loading capacity of drugs into the support, increase the solubility of drug and control drug release. In this study, poorly water-soluble, nonsteroidal anti-inflammatory drug with relatively low bioavailability Celecoxib, was used as a model drug in order to determine the drug loading and release properties of silica particles. In order to synthesize SBA15 particles, hydrothermal synthesis method was used, SBA-15 samples were functionalized by post-grafting method with (3-Aminopropyl) triethoxysilane, APTES (SBA-15-A). Moreover, Boron doped SBA-15 (SBA-15-B) samples were prepared and borosilicate samples were obtained. After APTES functionalization and Boron doping process, drug was loaded to the particles in three different solvents; ethanol, methanol and hexane to observe the effect on drug loading and release properties. Particle morphology and solvent effect on drug loading capacity of the silica particles were investigated and the effect of pH on drug release was studied. For this purpose, vi SBA-15 particles were characterized by using x-ray diffraction (XRD), small – angle x-ray spectrometry (SAXS), N2 adsorption - desorption, Fourier transform infra-red spectroscopy (FT-IR), differential scanning calorimetry (DSC), scanning electron microscope (SEM), transmission electron microscope (TEM), ultraviolet-visible spectrometry (UV-vis) and thermogravimetric analysis (TGA). Then, highly improved release rate of Celecoxib by using SBA-15 silica particles as drug carriers compared with the commercial drug, Celebrex. For the release experiments of the Celecoxib particles in all silica samples, phosphate buffer solution (PBS) was used in pH=7.4 and pH=5 at 37 ˚C. According to release results, slow release for SBA-15-A (APTES functionalized SBA-15) particles was observed, while there was burst release for SBA-15-B (Boron doped SBA-15) particles and all silica samples prepared by hexane solvent. All of the results demonstrated here confirm the potential use of silica supports as potential drug delivery carriers for poorly water soluble drugs.
Subject Keywords
Drugs
,
Drug delivery systems.
,
Celecoxib.
,
Silica.
URI
http://etd.lib.metu.edu.tr/upload/12620234/index.pdf
https://hdl.handle.net/11511/25850
Collections
Graduate School of Natural and Applied Sciences, Thesis
Suggestions
OpenMETU
Core
Surface functionalization of sba-15 particles for celecoxib delivery
Gezer, Gamze; Yılmaz, Ayşen; Department of Chemistry (2013)
Mesoporous silica particles have been used to enhance the loading capacity of drugs into these particles, increase bioavailability and control drug release. In this study SBA-15 particles were synthesized and functionalized to improve the loading capacity and release rate of drug. Then, drug loading and release process were investigated. Celecoxib was chosen as a model drug which is very hydrophobic. SBA-15 particles were used due to their highly ordered, well-defined mesoporous structure. These particles w...
Inclusion of celecoxib in the MCM – 41 mesoporous silica: drug loading and release property
Günaydin, Şahika; Yılmaz, Ayşen; Department of Chemistry (2014)
Mesoporous silica particles have been used to enhance the biocompability of the drugs and provide control drug release. Celecoxib was chosen as a model drug which is poorly water soluble non-steroidal anti-inflammatory drug. In this study, in order to determine the morphology effect on the drug loading capacity of the silica particles and release properties of the drug, MCM-41 particles were synthesized with different particle size, pore volume and surface properties. MCM-41-1 and MCM-41-2 labeled particles...
Improved solubility of celecoxib by inclusion in SBA-15 mesoporous silica: Drug loading in different solvents and release
Eren, Zeynep Seda; Tuncer, Sinem; Gezer, Gamze; Yildirim, Leyla Tatar; Banerjee, Sreeparna; Yılmaz, Ayşen (2016-11-15)
In this study, celecoxib (CLX), a highly hydrophobic nonsteroidal anti-inflammatory drug with relatively low bioavailability, was used as a model drug to determine loading in different solvents and release properties from silica particles. Hydrothermal synthesis method was used to synthesize SBA-15 particles, which were functionalized by post-synthesis grafting method with (3-Aminopropyl) triethoxysilane (APTES). Additionally, boron doped SBA-15 samples were prepared to generate borosilicate samples. After ...
Surface functionalization of SBA - 15 particles for amoxicillin delivery
Sevimli, Filiz F; Yılmaz, Ayşen; Department of Chemistry (2011)
There are several studies in order to control drug delivery, decrease the toxicity of drugs and also for novel biomedical applications. It is necessary to be able to control the release of the drug within the body by using drug delivery systems. Mesoporous silica compounds have only been discovered twenty years ago and they have already attracted many researchers to study these materials for several applications. SBA-15 particles have a highly ordered regular structure and are a good matrix for guest-host a...
Surface and modification of LP-SBA-15 with polyethyleneimine for celecoxib delivery
Farid, Ali; Yılmaz, Ayşen; Banerjee, Sreeparna; Department of Micro and Nanotechnology (2017)
In this study LP-SBA-15 (LP stands for large pores) and LP-SBA-15-PEI (PEI stands for polyethyleneimine), ordered mesoporous silica support material utilized with different pore structure characteristics to investigate on their drug delivery system abilities like release and loading properties, regarding to their structural variability and implication of surface modification. Hydrothermal synthesis method was used for synthesis of LP-SBA-15 and surface functionalization was done by polymerization of hyperbr...
Citation Formats
IEEE
ACM
APA
CHICAGO
MLA
BibTeX
Z. S. Eren, “Inclusion of celecoxib in the SBA-15 mesoporous silica: drug loading and release property,” M.S. - Master of Science, Middle East Technical University, 2016.
