Peripheral nerve conduits: Technology update

Date

2014-12-01

Author

Hasırcı, Nesrin
Arslantunalı Şahin, Damla
Hasırcı, Vasıf Nejat

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

127
views

0
downloads

Peripheral nerve injury is a worldwide clinical problem which could lead to loss of neuronal communication along sensory and motor nerves between the central nervous system (CNS) and the peripheral organs and impairs the quality of life of a patient. The primary requirement for the treatment of complete lesions is a tension-free, end-to-end repair. When end-to-end repair is not possible, peripheral nerve grafts or nerve conduits are used. The limited availability of autografts, and drawbacks of the allografts and xenografts like immunological reactions, forced the researchers to investigate and develop alternative approaches, mainly nerve conduits. In this review, recent information on the various types of conduit materials (made of biological and synthetic polymers) and designs (tubular, fibrous, and matrix type) are being presented.

Subject Keywords

Peripheral nerve injury, Natural biomaterials, Synthetic biomaterials

URI

https://hdl.handle.net/11511/31189

Journal

Medical Devices: Evidence and Research

DOI

https://doi.org/10.2147/mder.s59124

Collections

Graduate School of Natural and Applied Sciences, Article

Suggestions

OpenMETU
Core

DEVELOPMENT OF A COMPOSITE GUIDE FOR PERIPHERAL NERVE REGENERATION Arslantunalı Şahin, Damla; Son, Çağdaş Devrim; Hasırcı, Vasıf Nejat; Department of Biotechnology (2022-2-1) Any injury in peripheral nerves may result in a loss of neuronal communication along sensory and motor nerves, affecting patients’ daily activities. Today, there are various FDA approved commercial conduit materials; hollow tubes preventing them from used in gaps bigger than 10 mm, because they may lead axonal sprouts to form. The presented study includes pHEMA wrapping structure filled with GelMA-HaMA gel matrix as a nerve guidance channel. Following the structural analysis of the nerve guide, in vitro stu...
Multiwalled CNT-pHEMA composite conduit for peripheral nerve repair. Arslantunalı Şahin, Damla; Hasırcı, Vasıf Nejat (2014-03-01) A nerve conduit is designed to improve peripheral nerve regeneration by providing guidance to the nerve cells. Conductivity of such guides is reported to enhance this process. In the current study, a nerve guide was constructed from poly(2-hydroxyethyl methacrylate) (pHEMA), which was loaded with multiwalled carbon nanotubes (mwCNT) to introduce conductivity. PHEMA hydrogels were designed to have a porous structure to facilitate the transportation of the compounds needed for cell nutrition and growth and al...
Tissue Engineered, Guided Nerve Tube Consisting of Aligned Neural Stem Cells and Astrocytes Yucel, Deniz; Kose, Gamze Torun; Hasırcı, Vasıf Nejat (2010-12-01) Injury of the nervous system, particularly in the spinal cord, impairs the quality of life of the patient by resulting in permanent loss of neurologic function. The main limitation in spinal cord regeneration is the lack of extracellular matrix to guide nerves for functional recovery of the transected nerve tissue. In the present study, a tissue engineered nerve tube was prepared by wrapping neural stem cells (NSCs) on aligned fibers using a micropatterned film with astrocytes aligned along the microgrooves...
Study on the influence of scaffold inner organization on the treatment of spinal cord injury Dursun, Tuğba; Hasırcı, Deniz; Yücel, Deniz; Department of Biotechnology (2013) Permanent loss of neurologic function occurs when the central nervous system (CNS) is injured. Nerve regeneration is extremely limited because of dense scar tissue formation at the lesion site, especially in the spinal cord. For the treatment of this type of injury, different strategies are needed. The emerging approach to solve these problems is to provide a physical support via tubular bridging devices such as “nerve guides”. They are used to bridge the neural gaps in the treatment of spinal cord injury, ...
A Bio and synthetic polymer based nerve guide tested under in vitro and in vivo conditions Dursun Usal, Tuğba; Hasırcı, Vasıf Nejat; Department of Biotechnology (2019) Damages to the peripheral nervous system due to age, diseases or trauma may lead to gap formation in nervous tissue and inhibit signal transfer. Nerve guides are used to bridge the neural gaps created as a result of these events. This study describes the design, construction, and testing of a nerve guide which carries inner guidance elements to provide an appropriate microenvironment for peripheral nerve regeneration. A methacrylated gelatin-poly(2-hydroxyethyl methacrylate) (GelMA-pHEMA) hydrogel and 3D pr...

Citation Formats

N. Hasırcı, D. Arslantunalı Şahin, and V. N. Hasırcı, “Peripheral nerve conduits: Technology update,” Medical Devices: Evidence and Research, pp. 405–424, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31189.