Peripheral nerve conduits: Technology update

Peripheral nerve injury is a worldwide clinical problem which could lead to loss of neuronal communication along sensory and motor nerves between the central nervous system (CNS) and the peripheral organs and impairs the quality of life of a patient. The primary requirement for the treatment of complete lesions is a tension-free, end-to-end repair. When end-to-end repair is not possible, peripheral nerve grafts or nerve conduits are used. The limited availability of autografts, and drawbacks of the allografts and xenografts like immunological reactions, forced the researchers to investigate and develop alternative approaches, mainly nerve conduits. In this review, recent information on the various types of conduit materials (made of biological and synthetic polymers) and designs (tubular, fibrous, and matrix type) are being presented.
Medical Devices: Evidence and Research


Arslantunalı Şahin, Damla; Son, Çağdaş Devrim; Hasırcı, Vasıf Nejat; Department of Biotechnology (2022-2-1)
Any injury in peripheral nerves may result in a loss of neuronal communication along sensory and motor nerves, affecting patients’ daily activities. Today, there are various FDA approved commercial conduit materials; hollow tubes preventing them from used in gaps bigger than 10 mm, because they may lead axonal sprouts to form. The presented study includes pHEMA wrapping structure filled with GelMA-HaMA gel matrix as a nerve guidance channel. Following the structural analysis of the nerve guide, in vitro stu...
Multiwalled CNT-pHEMA composite conduit for peripheral nerve repair.
Arslantunalı Şahin, Damla; Hasırcı, Vasıf Nejat (2014-03-01)
A nerve conduit is designed to improve peripheral nerve regeneration by providing guidance to the nerve cells. Conductivity of such guides is reported to enhance this process. In the current study, a nerve guide was constructed from poly(2-hydroxyethyl methacrylate) (pHEMA), which was loaded with multiwalled carbon nanotubes (mwCNT) to introduce conductivity. PHEMA hydrogels were designed to have a porous structure to facilitate the transportation of the compounds needed for cell nutrition and growth and al...
Tissue Engineered, Guided Nerve Tube Consisting of Aligned Neural Stem Cells and Astrocytes
Yucel, Deniz; Kose, Gamze Torun; Hasırcı, Vasıf Nejat (2010-12-01)
Injury of the nervous system, particularly in the spinal cord, impairs the quality of life of the patient by resulting in permanent loss of neurologic function. The main limitation in spinal cord regeneration is the lack of extracellular matrix to guide nerves for functional recovery of the transected nerve tissue. In the present study, a tissue engineered nerve tube was prepared by wrapping neural stem cells (NSCs) on aligned fibers using a micropatterned film with astrocytes aligned along the microgrooves...
Association analysis of glutathione s-transferase omega 1 and omega 2 genetic polymorphisms and ischemic stroke risk in Turkish population
Bilgin, Esra; Adalı, Orhan; Department of Biochemistry (2014)
Stroke is defined as the acute neurological cerebrovascular disease based on interruptions to blood flow in the brain. These interruptions are caused by loss of blood supply due to vessel bursts or vessel blocked by clotting. Atherosclerosis, a main cause of stroke, is blockage of endothelium layer of arteries and losing the flexibility of tissue. The oxidative stress is known as a risk factor for atherosclerosis. The increased free radicals such as reactive oxygen species (ROS) and decreased antioxidant le...
Study on the influence of scaffold inner organization on the treatment of spinal cord injury
Dursun, Tuğba; Hasırcı, Deniz; Yücel, Deniz; Department of Biotechnology (2013)
Permanent loss of neurologic function occurs when the central nervous system (CNS) is injured. Nerve regeneration is extremely limited because of dense scar tissue formation at the lesion site, especially in the spinal cord. For the treatment of this type of injury, different strategies are needed. The emerging approach to solve these problems is to provide a physical support via tubular bridging devices such as “nerve guides”. They are used to bridge the neural gaps in the treatment of spinal cord injury, ...
Citation Formats
N. Hasırcı, D. Arslantunalı Şahin, and V. N. Hasırcı, “Peripheral nerve conduits: Technology update,” Medical Devices: Evidence and Research, pp. 405–424, 2014, Accessed: 00, 2020. [Online]. Available: