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Peripheral nerve conduits: Technology update
Date
2014-12-01
Author
Hasırcı, Nesrin
Arslantunalı Şahin, Damla
Hasırcı, Vasıf Nejat
Metadata
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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Peripheral nerve injury is a worldwide clinical problem which could lead to loss of neuronal communication along sensory and motor nerves between the central nervous system (CNS) and the peripheral organs and impairs the quality of life of a patient. The primary requirement for the treatment of complete lesions is a tension-free, end-to-end repair. When end-to-end repair is not possible, peripheral nerve grafts or nerve conduits are used. The limited availability of autografts, and drawbacks of the allografts and xenografts like immunological reactions, forced the researchers to investigate and develop alternative approaches, mainly nerve conduits. In this review, recent information on the various types of conduit materials (made of biological and synthetic polymers) and designs (tubular, fibrous, and matrix type) are being presented.
Subject Keywords
Peripheral nerve injury
,
Natural biomaterials
,
Synthetic biomaterials
URI
https://hdl.handle.net/11511/31189
Journal
Medical Devices: Evidence and Research
DOI
https://doi.org/10.2147/mder.s59124
Collections
Graduate School of Natural and Applied Sciences, Article
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DEVELOPMENT OF A COMPOSITE GUIDE FOR PERIPHERAL NERVE REGENERATION
Arslantunalı Şahin, Damla; Son, Çağdaş Devrim; Hasırcı, Vasıf Nejat; Department of Biotechnology (2022-2-1)
Any injury in peripheral nerves may result in a loss of neuronal communication along sensory and motor nerves, affecting patients’ daily activities. Today, there are various FDA approved commercial conduit materials; hollow tubes preventing them from used in gaps bigger than 10 mm, because they may lead axonal sprouts to form. The presented study includes pHEMA wrapping structure filled with GelMA-HaMA gel matrix as a nerve guidance channel. Following the structural analysis of the nerve guide, in vitro stu...
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Permanent loss of neurologic function occurs when the central nervous system (CNS) is injured. Nerve regeneration is extremely limited because of dense scar tissue formation at the lesion site, especially in the spinal cord. For the treatment of this type of injury, different strategies are needed. The emerging approach to solve these problems is to provide a physical support via tubular bridging devices such as “nerve guides”. They are used to bridge the neural gaps in the treatment of spinal cord injury, ...
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Dursun Usal, Tuğba; Hasırcı, Vasıf Nejat; Department of Biotechnology (2019)
Damages to the peripheral nervous system due to age, diseases or trauma may lead to gap formation in nervous tissue and inhibit signal transfer. Nerve guides are used to bridge the neural gaps created as a result of these events. This study describes the design, construction, and testing of a nerve guide which carries inner guidance elements to provide an appropriate microenvironment for peripheral nerve regeneration. A methacrylated gelatin-poly(2-hydroxyethyl methacrylate) (GelMA-pHEMA) hydrogel and 3D pr...
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N. Hasırcı, D. Arslantunalı Şahin, and V. N. Hasırcı, “Peripheral nerve conduits: Technology update,”
Medical Devices: Evidence and Research
, pp. 405–424, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31189.