Peripheral nerve conduits: Technology update

Date

2014-12-01

Author

Hasırcı, Nesrin
Arslantunalı Şahin, Damla
Hasırcı, Vasıf Nejat

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

289
views

0
downloads

Peripheral nerve injury is a worldwide clinical problem which could lead to loss of neuronal communication along sensory and motor nerves between the central nervous system (CNS) and the peripheral organs and impairs the quality of life of a patient. The primary requirement for the treatment of complete lesions is a tension-free, end-to-end repair. When end-to-end repair is not possible, peripheral nerve grafts or nerve conduits are used. The limited availability of autografts, and drawbacks of the allografts and xenografts like immunological reactions, forced the researchers to investigate and develop alternative approaches, mainly nerve conduits. In this review, recent information on the various types of conduit materials (made of biological and synthetic polymers) and designs (tubular, fibrous, and matrix type) are being presented.

Subject Keywords

Peripheral nerve injury, Natural biomaterials, Synthetic biomaterials

URI

https://hdl.handle.net/11511/31189

Journal

Medical Devices: Evidence and Research

DOI

https://doi.org/10.2147/mder.s59124

Collections

Graduate School of Natural and Applied Sciences, Article

Suggestions

OpenMETU
Core

DEVELOPMENT OF A COMPOSITE GUIDE FOR PERIPHERAL NERVE REGENERATION Arslantunalı Şahin, Damla; Son, Çağdaş Devrim; Hasırcı, Vasıf Nejat; Department of Biotechnology (2022-2-1) Any injury in peripheral nerves may result in a loss of neuronal communication along sensory and motor nerves, affecting patients’ daily activities. Today, there are various FDA approved commercial conduit materials; hollow tubes preventing them from used in gaps bigger than 10 mm, because they may lead axonal sprouts to form. The presented study includes pHEMA wrapping structure filled with GelMA-HaMA gel matrix as a nerve guidance channel. Following the structural analysis of the nerve guide, in vitro stu...
Multiwalled CNT-pHEMA composite conduit for peripheral nerve repair. Arslantunalı Şahin, Damla; Hasırcı, Vasıf Nejat (2014-03-01) A nerve conduit is designed to improve peripheral nerve regeneration by providing guidance to the nerve cells. Conductivity of such guides is reported to enhance this process. In the current study, a nerve guide was constructed from poly(2-hydroxyethyl methacrylate) (pHEMA), which was loaded with multiwalled carbon nanotubes (mwCNT) to introduce conductivity. PHEMA hydrogels were designed to have a porous structure to facilitate the transportation of the compounds needed for cell nutrition and growth and al...
Association analysis of glutathione s-transferase omega 1 and omega 2 genetic polymorphisms and ischemic stroke risk in Turkish population Bilgin, Esra; Adalı, Orhan; Department of Biochemistry (2014) Stroke is defined as the acute neurological cerebrovascular disease based on interruptions to blood flow in the brain. These interruptions are caused by loss of blood supply due to vessel bursts or vessel blocked by clotting. Atherosclerosis, a main cause of stroke, is blockage of endothelium layer of arteries and losing the flexibility of tissue. The oxidative stress is known as a risk factor for atherosclerosis. The increased free radicals such as reactive oxygen species (ROS) and decreased antioxidant le...
Tissue Engineered, Guided Nerve Tube Consisting of Aligned Neural Stem Cells and Astrocytes Yucel, Deniz; Kose, Gamze Torun; Hasırcı, Vasıf Nejat (2010-12-01) Injury of the nervous system, particularly in the spinal cord, impairs the quality of life of the patient by resulting in permanent loss of neurologic function. The main limitation in spinal cord regeneration is the lack of extracellular matrix to guide nerves for functional recovery of the transected nerve tissue. In the present study, a tissue engineered nerve tube was prepared by wrapping neural stem cells (NSCs) on aligned fibers using a micropatterned film with astrocytes aligned along the microgrooves...
Genetic polymorphism of vitamin D3 metabolising cytochrome p450 (CYPS) enyzmes and risk of ischemic stroke in Turkish population Öner, Tuğçe; Adalı, Orhan; Can Demirdöğen, Birsen; Department of Biochemistry (2015) Stroke, as a neurological disorder, is defined as cessation or severe reduction of blood flow to the brain due to a clot or burst of blood vessel in the brain. Atherosclerosis is the hardening of the arteries due to accumulation of plaques in the vessels. Vitamin D deficiency is known as important risk factor in pathogenesis of atherosclerosis, which contributes to stroke development. Incidence of stroke is affected by environmental and genetic risk factors. So, genetic variations including single nucleotid...

Citation Formats

N. Hasırcı, D. Arslantunalı Şahin, and V. N. Hasırcı, “Peripheral nerve conduits: Technology update,” Medical Devices: Evidence and Research, pp. 405–424, 2014, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31189.