Tailoring the magnetic behavior of polymeric particles for bioapplications

Tansik, Gulistan
Keskin, Tugba
Gündüz, Ufuk
In this study, magnetic polymeric nanoparticles were prepared use in for targeted drug delivery. First, iron oxide (Fe3O4) magnetic nanoparticles (MNPs) were synthesized by coprecipitation with ferrous and ferric chloride salts. Then, to render the MNPs hydrophobic, the surfaces were covered with oleic acid. Finally, the hydrophobic MNPs (H-MNPs) were encapsulated with polymer. The emulsion evaporation technique was used for the preparation of polymer-coated H-MNP. Poly(DL-lactide-co-glycolide) (PLGA) and chitosan-modified PLGA were used as polymers. The polymeric nanoparticles were characterized and compared. X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, small-angle X-ray scattering, size distribution, zeta potential, magnetic properties, and magnetite entrapment efficiency measurements were performed to investigate the properties of the nanoparticles. The XTT assay was performed to understand the biocompatibility (i.e., toxicity) of MNPs and magnetic polymeric nanoparticles to MCF-7 cells.


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AYDIN, Ozlem; AYDIN, Baran; Tezcaner, Ayşen; Keskin, Dilek (2015-04-10)
This study aimed to develop drug delivery system of doxycycline-loaded polycaprolactone (PCL) microspheres. The investigated microsphere formulation can be considered for local application in bone infections and degenerative joint diseases, which generally require long-term treatments via systemic drugs. PCL-14 kDa and 65 kDa were used in microsphere preparation. Before release, the microspheres were characterized by scanning electron microscopy, differential scanning calorimetry, and X-ray photoelectron sp...
Core/shell type, Ce3+ and Tb3+ doped GdBO3 system: Synthesis and Celecoxib drug delivery application
Çolak, Pelin; Ulusan, Sinem; Banerjee, Sreeparna; Yılmaz, Ayşen (Elsevier BV, 2020-12-01)
In this study, luminescent and magnetic core/shell Gd1-x-yCexTbyBO3@SiO2 nanoparticles were synthesized and used to design a drug delivery system for Celecoxib (CLX). CLX was chosen as the model drug because it is a nonsteroidal anti-inflammatory drug that is highly hydrophobic with relatively low bioavailability. The core was synthesized by Pechini sol-gel method and silica coating was carried out by a Modified Stöber method. Drug loading was carried out in ethanol with high efficiency and an improved drug...
Synthesis and characterization of polymeric magnetic nanoparticles loaded by gemcitabine /
Parsian, Maryam; Gündüz, Ufuk; Tezcaner, Ayşen; Department of Biotechnology (2014)
In this study, different types of magnetic nanoparticles were synthesized for treatment of breast cancer by targeted drug delivery. Polyamidoamine (PAMAM) dendrimer, Chitosan (CS) and Polyhydroxybutyrate (PHB) coated magnetic nanoparticles were prepared and loaded with Gemcitabine. The loading efficiency of drug for various half generations of dendrimer coated magnetic nanoparticles (DcMNPs), Chitosan coated magnetic nanoparticles (CSMNPs) and Polyhydroxybutyrate magnetic nanoparticles (PHB-MNPs) were inves...
Biopolymer based micro/nanoparticles as drug carriers for the treatment of skin diseases
Eke, Gözde; Hasırcı, Vasıf Nejat; Hasırcı, Nesrin; Department of Micro and Nanotechnology (2011)
Controlled drug delivery systems are becoming increasingly interesting with the contribution of nanotechnology. In the case of transdermal applications the greatest limitation is the highly impermeable outermost layer of the skin, the stratum corneum. One promising method of controlled transdermal drug delivery of the skin therapeutics is the use of nanoparticles as carriers. Encapsulation of the drug, as opposed to classical topical application of creams or emulsions, allows the drug to diffuse into hair f...
Fatty acid based hyperbranched polymeric nanoparticles for hydrophobic drug delivery
Guc, Esra; GÜNDÜZ, GÜNGÖR; Gündüz, Ufuk (2010-10-01)
Background: In recent years nano-sized dendrimer/hyperbranched polymers gained importance in drug delivery applications. Objective: In this study, a novel fatty acid-based hyperbranched resin (HBR) was synthesized and used for tamoxifen (TAM) and idarubicin (IDA) delivery. Methods: The core of the HBR was dipentaerythritol, and the branching was provided by dimethylolpropionic acid. The molecule was terminated by ricinoleic acid. Chemical and structural characterization of the resin was carried out and then...
Citation Formats
A. YAKAR, G. Tansik, T. Keskin, and U. Gündüz, “Tailoring the magnetic behavior of polymeric particles for bioapplications,” JOURNAL OF POLYMER ENGINEERING, pp. 265–274, 2013, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31311.