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Study on physiochemical structure and in vitro release behaviors of doxycycline-loaded PCL microspheres
Date
2015-04-10
Author
AYDIN, Ozlem
AYDIN, Baran
Tezcaner, Ayşen
Keskin, Dilek
Metadata
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Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License
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This study aimed to develop drug delivery system of doxycycline-loaded polycaprolactone (PCL) microspheres. The investigated microsphere formulation can be considered for local application in bone infections and degenerative joint diseases, which generally require long-term treatments via systemic drugs. PCL-14 kDa and 65 kDa were used in microsphere preparation. Before release, the microspheres were characterized by scanning electron microscopy, differential scanning calorimetry, and X-ray photoelectron spectroscopy. The mean particle size of microspheres was in the range of 74-122 mu m and their drug loadings ranged between 10 and 30%. In vitro release profiles were described using the Higuchi and the Korsmeyer-Peppas equations. Diffusion model was applied to experimental data for estimating diffusion coefficients of microspheres; calculated as between 4.5 x 10(-10) and 9.5 x 10(-10) cm(2)/s. Although long-term release from microspheres of PCL-14 kDa obeyed diffusion model, PCL-65 kDa microspheres showed this tendency only for some period. Modeling studies showed that the drug release mechanism was mainly dependent on loading and molecular weight differences. Release behavior of PCL-65 kDa microspheres, however, might be better represented by derivation of a different equation to model for the total release period. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41768
Subject Keywords
Theory and modeling
,
Properties and characterization
,
Kinetics
,
Drug delivery systems
,
Biodegradable
URI
https://hdl.handle.net/11511/43166
Journal
JOURNAL OF APPLIED POLYMER SCIENCE
DOI
https://doi.org/10.1002/app.41768
Collections
Department of Engineering Sciences, Article
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O. AYDIN, B. AYDIN, A. Tezcaner, and D. Keskin, “Study on physiochemical structure and in vitro release behaviors of doxycycline-loaded PCL microspheres,”
JOURNAL OF APPLIED POLYMER SCIENCE
, pp. 0–0, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/43166.