Role of ABCB1 and ABCC1 Gene Induction on Survival in Locally Advanced Breast Cancer

Atalay, C.
Gündüz, Ufuk
Drug resistance to chemotherapy in patients with locally advanced breast cancer results in a decrease in treatment efficacy and in patient survival. This study aimed to evaluate the impact of ABCB1 and ABCC1 gene induction during chemotherapy on disease-free and overall survival of breast cancer patients.


The Roles of protein kinase d2 in chemoresistant breast cancer cell lines
Alpsoy, Aktan; Gündüz, Ufuk; Department of Biology (2014)
Even though chemotherapy keeps its position as the most preferred and potent strategy of cancer treatment, resistance of tumor to the anti-neoplastic drug poses an obstacle for chemotherapy success. Multidrug resistance (MDR) is a phenomenon that is defined as the intrinsic or acquired resistance against structurally and functionally unrelated drugs. Acquisition of multidrug resistance can be through several distinct mechanisms such as increased drug efflux by ABC transporters, increased drug detoxification...
Development and investigation of etoposide resistance in MCF-7 Breast cancer cell line
Kaplan, Esra; Gündüz, Ufuk; Department of Biology (2010)
Failure of chemotherapy in cancer patients because of development of drug resistance is a major problem. Alterations of DNA repair mechanisms and drug targets are among the important resistance mechanisms which are developed against topoisomerase II inhibitors etoposide and doxorubicin. Modifications in the expression levels of mismatch repair (MMR) genes due to resistance to topoisomerase II inhibitors are involved in breast cancer. In this study, etoposide resistant sublines were developed from MCF7 breas...
Expression analysis of TOP2A, MSH2 and MLH1 genes in MCF7 cells at different levels of etoposide resistance
Kaplan, Esra; Gündüz, Ufuk (2012-02-01)
Purpose: Development of resistance against anti-cancer drugs is one of the major obstacles of chemotherapy in the treatment of cancer. Etoposide is a topoisomerase II alpha (TOP2A) inhibitor, which is used in the treatment of breast cancer. Alterations in the expression of drug targets or DNA repair genes are among the important resistance mechanisms against TOP2A inhibitors. In this study, expression changes in TOP2A gene and two important mismatch repair (MMR) genes MSH2 and MLH1 were examined in order to...
Reversal of breast cancer resistance protein mediated multidrug resistance in MCF7 breast adenocarcinoma cell line
Urfalı, Çağrı; Gündüz, Ufuk; Department of Biology (2011)
Resistance to various chemotherapeutic agents is a major problem in success of cancer chemotherapy. One of the primary reasons of development of multidrug resistance (MDR) is the overexpression of ATP binding cassette (ABC) transporter proteins. Breast cancer resistance protein (BCRP) belongs to ABC transporter family and encoded by ABCG2 gene. BCRP is mainly expressed in MDR1 (P-glycoprotein) lacking breast cancer cells. Overexpression of BCRP leads to efflux of chemotherapeutic agents at higher rates, the...
Effect of cisplatin-metformin drug combination on GSTP1 mediated apoptosis
Durukan, Özlem; Arslan, Şevki; Adalı, Orhan (null; 2017-09-08)
Kllng cancer cells by trggerng cellular apoptoss seems to be the prevalent acton mechansm for cancer drugs. Usng substances that targetng the enzymes partcpatng n the apoptotc pathways that trggers the cellular apoptoss can be a useful treatment opton for cancer. GSTP enzyme, ts newly known role as a modulator of cellular survval and death, can be a good proten molecule for cancer studes. Although, csplatn as one of the most potent alkylatng agent that appled wth success n vast majorty of cancers, ts sde ef...
Citation Formats
C. Atalay, A. DEMİRKAZIK, and U. Gündüz, “Role of ABCB1 and ABCC1 Gene Induction on Survival in Locally Advanced Breast Cancer,” JOURNAL OF CHEMOTHERAPY, pp. 734–739, 2008, Accessed: 00, 2020. [Online]. Available: