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Development of a Reconstructed Cornea from Collagen-Chondroitin Sulfate Foams and Human Cell Cultures

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2008-12-01
Vrana, N. Engin
Builles, Nicolas
Justin, Virginie
Bednarz, Jurgen
Pellegrini, Graziella
Ferrari, Barbara
Damour, Odile
Hulmes, David J. S.
Hasırcı, Vasıf Nejat
PURPOSE. To develop an artificial cornea, the ability to coculture the different cell types present in the cornea is essential. Here the goal was to develop a full-thickness artificial cornea using an optimized collagen-chondroitin sulfate foam, with a thickness close to that of human cornea, by coculturing human corneal epithelial and stromal cells and transfected human endothelial cells.