Drug resistant MCF-7 cells exhibit epithelial-mesenchymal transition gene expression pattern

Date

2011-02-01

Author

Iseri, Ozlem Darcansoy
Kars, Meltem Demirel
Arpaci, Fikret
Atalay, Can
Pak, Isin
Gündüz, Ufuk

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Purpose: Multidrug resistance is resistance to structurally unrelated anticancer agents. Large-scale expression analysis by using high-density oligonucleotide microarrays may provide information about new candidate genes contributing to MDR. This study demonstrates alterations in expression levels of several genes related to epithelial-mesenchymal transition (EMT) in paclitaxel, docetaxel, and doxorubicin resistant MCF-7 cells.

Subject Keywords

Multidrug resistance, EMT, Breast cancer

URI

https://hdl.handle.net/11511/31655

Journal

BIOMEDICINE & PHARMACOTHERAPY

DOI

https://doi.org/10.1016/j.biopha.2010.10.004

Collections

Graduate School of Natural and Applied Sciences, Article