Multidrug Resistance Mediated by MRP1 Gene Overexpression in Breast Cancer Patients

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Date

2009-01-01

Author

Abaan, Ogan Demir
Mutlu, Pelin
Baran, Yusuf
Atalay, Can
Gündüz, Ufuk

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Multidrug resistance (MDR) is a serious handicap towards the effective treatment of breast cancer patients. One of the most prevalent MDR mechanisms is through the overexpression of genes coding the proteins called Multidrug Resistance-associated Proteins (MRPs). The aim of this study was to investigate the expression of MRP1 in tumor tissues from breast cancer patients. In this study, a semi-quantitative RT-PCR approach was utilized. Our results suggest that MRP1 overexpression can mediate MDR in patients. Pre-evaluation of the level of such MDR mediators before chemotherapy can increase the efficacy of the treatment.

Subject Keywords

Multidrug resistance, MDR, MRP1, Breast cancer, Chemotherapy, MRP Family

URI

https://hdl.handle.net/11511/31683

Journal

CANCER INVESTIGATION

DOI

https://doi.org/10.1080/07357900802173562

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

O. D. Abaan, P. Mutlu, Y. Baran, C. Atalay, and U. Gündüz, “Multidrug Resistance Mediated by MRP1 Gene Overexpression in Breast Cancer Patients,” CANCER INVESTIGATION, pp. 201–205, 2009, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31683.