Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance

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Date

2007-12-01

Author

BARAN, YUSUF
Guer, Bala
Kaya, Pelin
Ural, Ali Ugur
Avcu, Ferit
Gündüz, Ufuk

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The major problem in the treatment of acute myeloid leukemia (AML) patients results from multidrug resistance to administered anticancer agents. Drug resistance proteins, MDR1 and MRP1, which work as drug efflux pumps, can mediate the multidrug resistance of human leukemia cells. In this study, the mechanisms of resistance to doxorubicin-induced cell death in human HL60 AML cells were examined.

Subject Keywords

Multidrug resistance, MDR1, MRP1, AML, Doxorubicin, Cytosine arabinoside

URI

https://hdl.handle.net/11511/30738

Journal

HEMATOLOGY

DOI

https://doi.org/10.1080/10245330701562535

Collections

Graduate School of Natural and Applied Sciences, Article

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Citation Formats

Y. BARAN, B. Guer, P. Kaya, A. U. Ural, F. Avcu, and U. Gündüz, “Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance,” HEMATOLOGY, pp. 511–517, 2007, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30738.