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Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance
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Date
2007-12-01
Author
BARAN, YUSUF
Guer, Bala
Kaya, Pelin
Ural, Ali Ugur
Avcu, Ferit
Gündüz, Ufuk
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The major problem in the treatment of acute myeloid leukemia (AML) patients results from multidrug resistance to administered anticancer agents. Drug resistance proteins, MDR1 and MRP1, which work as drug efflux pumps, can mediate the multidrug resistance of human leukemia cells. In this study, the mechanisms of resistance to doxorubicin-induced cell death in human HL60 AML cells were examined.
Subject Keywords
Multidrug resistance
,
MDR1
,
MRP1
,
AML
,
Doxorubicin
,
Cytosine arabinoside
URI
https://hdl.handle.net/11511/30738
Journal
HEMATOLOGY
DOI
https://doi.org/10.1080/10245330701562535
Collections
Graduate School of Natural and Applied Sciences, Article
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Y. BARAN, B. Guer, P. Kaya, A. U. Ural, F. Avcu, and U. Gündüz, “Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance,”
HEMATOLOGY
, pp. 511–517, 2007, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/30738.