Nanoparticles Based Drug Delivery Systems to Overcome Multidrug Resistance in Cancer The Role of Membrane Lipids Proteins and Carbohydrates

2016-09-28
Özlüer, Özlem
Yalçın Azarkan, Serap
Gündüz, Ufuk
Multidrug resistance (MDR) is a major problem in success of cancer chemotherapy on tumor cell growth, limits the prolonged and effective use of chemotherapy. The use of nanomaterial based drug carriers in cancer treatment offers exciting opportunities to enhance delivery of therapeutics to the tumor site (1). This is also known as targeted drug delivery providing differential distribution of drugs to the tumor site while significantly reducing the overall toxicity. Here, we critically discuss the role of the membrane lipids, protein and carbohydrates in nanoparticle based drug carrier systems in relation to the resistance. Results obtained in recent years indicate the important roles of lipids, proteins, or carbohydrates in regulating membrane pump/channels function, membrane trafficking, signaling transduction pathways, apoptotic pathways, and endocytosis, the primary mechanism of cellular uptake of nanoparticle based drug delivery systems(2). This review highlighted the need for continuing research on the interactions between the nanoparticles and the molecules on the cell membrane to overcome drug resistance.
WITAM -2016 2nd International Congress on the World of Technology and Advanced Materials (28 Eylül - 02 Ekim 2016)

Suggestions

Nanoparticle-based drug delivery in cancer: the role of cell membrane structures
Yalcin, Serap; Ozluer, Ozlem; Gündüz, Ufuk (2016-11-01)
Development of novel drug-delivery systems aims to specifically deliver anticancer drugs to tumor tissues and improve the efficiency of chemotherapy, while minimizing side effects of drugs on healthy tissues and organs. However, drug-delivery systems are confronted by membrane barriers and multiple drug resistance in cancer cells. In recent years, the obtained results indicate an important role of lipids, proteins and carbohydrates in apoptosis, drug transport and the process of cellular uptake of nanoparti...
Synthesis of poly (dl-lactic-co-glycolic acid) coated magnetic nanoparticles for anti-cancer drug delivery
Tansık, Gülistan; Gündüz, Ufuk; Department of Biology (2012)
One of the main problems of current cancer chemotherapy is the lack of selectivity of anti-cancer drugs to tumor cells which leads to systemic toxicity and adverse side effects. In order to overcome these limitations, researches on controlled drug delivery systems have gained much attention. Nanoscale based drug delivery systems provide tumor targeting. Among many types of nanocarriers, superparamagnetic nanoparticles with their biocompatible polymer coatings can be targeted to an intented site by an extern...
Folic acid-conjugated polyethylene glycol-coated magnetic nanoparticles for doxorubicin delivery in cancer chemotherapy: Preparation, characterization and cytotoxicity on HeLa cell line
Erdem, Murat; Gündüz, Ufuk (2017-08-01)
Conventional chemotherapy is the most valid method to cope with cancer; however, it has serious drawbacks such as decrease in production of blood cells or inflammation of the lining of the digestive tract. These side effects occur since generally the drugs used in chemotherapy are distributed evenly within the body of the patient and cannot distinguish the cancer cells from the healthy ones. In this study, folic acid (FA)-conjugated, polyethylene-coated magnetic nanoparticles (FA-MNPs), and doxorubicin (Dox...
Paclitaxel Resistance in MCF-7/Pac Cell Line is Reversed Successfully by Saikosaponin A and Saikosaponin D
DEMİREL KARS, MELTEM; KARS, GÖKHAN; Gündüz, Ufuk (2013-01-01)
Cancer cells demonstrate multiple drug resistance phenotype frequently after chemotherapy. The resistance of cancer cells to various chemotherapeutic agents is defined as multiple drug resistance. The purpose of this study is to investigate the potential reversal effects of active agents, that are found high amount in plants, on resistant MCF-7 cell lines. The effects of potential MDR modulators combined with anticancer drugs were also evaluated. Flow cytometry, fluorescence microscopy and checkerboard comb...
Multiscale tumor modeling
Ünsal, Serbülent; Acar, Aybar Can; Department of Health Informatics (2014)
Cancer’s complex behavior decreases success rates of the cancer therapies. The usual steps cancer therapy are, deciding phase of the cancer and planing the therapy according to medical guidelines and there is no room or chance for personalized medicine. Simulation systems that use patient specific data as input and up-to-date scientific evidence as business rules has chance to help clinicians for evidence based personalized medicine practice.In this study our aim is creating a basic model to guide researche...
Citation Formats
Ö. Özlüer, S. Yalçın Azarkan, and U. Gündüz, “Nanoparticles Based Drug Delivery Systems to Overcome Multidrug Resistance in Cancer The Role of Membrane Lipids Proteins and Carbohydrates,” presented at the WITAM -2016 2nd International Congress on the World of Technology and Advanced Materials (28 Eylül - 02 Ekim 2016), Kırşehir, Türkiye, 2016, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/77973.