Nanoparticles Based Drug Delivery Systems to Overcome Multidrug Resistance in Cancer The Role of Membrane Lipids Proteins and Carbohydrates

2016-09-28
Özlüer, Özlem
Yalçın Azarkan, Serap
Gündüz, Ufuk
Multidrug resistance (MDR) is a major problem in success of cancer chemotherapy on tumor cell growth, limits the prolonged and effective use of chemotherapy. The use of nanomaterial based drug carriers in cancer treatment offers exciting opportunities to enhance delivery of therapeutics to the tumor site (1). This is also known as targeted drug delivery providing differential distribution of drugs to the tumor site while significantly reducing the overall toxicity. Here, we critically discuss the role of the membrane lipids, protein and carbohydrates in nanoparticle based drug carrier systems in relation to the resistance. Results obtained in recent years indicate the important roles of lipids, proteins, or carbohydrates in regulating membrane pump/channels function, membrane trafficking, signaling transduction pathways, apoptotic pathways, and endocytosis, the primary mechanism of cellular uptake of nanoparticle based drug delivery systems(2). This review highlighted the need for continuing research on the interactions between the nanoparticles and the molecules on the cell membrane to overcome drug resistance.
Citation Formats
Ö. Özlüer, S. Yalçın Azarkan, and U. Gündüz, “Nanoparticles Based Drug Delivery Systems to Overcome Multidrug Resistance in Cancer The Role of Membrane Lipids Proteins and Carbohydrates,” presented at the WITAM -2016 2nd International Congress on the World of Technology and Advanced Materials (28 Eylül - 02 Ekim 2016), Kırşehir, Türkiye, 2016, Accessed: 00, 2021. [Online]. Available: https://hdl.handle.net/11511/77973.