Evaluation of Whole Genome Association Study Data in Bipolar Disorders: Potential Novel SNPs and Genes

Date

2015-03-01

Author

CENGİZ HAN, Açıkel
Aydın Son, Yeşim
ÇELİK, Cemil
RECEP, Tütüncü

Metadata

Show full item record

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Item Usage Stats

210
views

0
downloads

Objective: As a result of studies of multifactorial conditions, genetic, physiological and environmental factors, the overall heritability of bipolar disorders has been estimated to be up to 70%. In this study, an analysis of genome-wide association study data using data mining algorithms has revealed single-nucleotide polymorphisms that may be the basis for the molecular etiology of bipolar disorders.

Subject Keywords

Bipolar disorders, GWAS, ZNF507, DOCK10, Zinc finger protein, Chromosome 19

URI

https://hdl.handle.net/11511/31685

Journal

KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY

DOI

https://doi.org/10.5455/bcp.20150108111830

Collections

Graduate School of Informatics, Article

Suggestions

OpenMETU
Core

Investigating the role of RNA-binding proteins (RBPS) in explaining differential gene expression in cancer Lafzi, Atefeh; Aydın Son, Yeşim; Kazan, Hilal; Department of Bioinformatics (2016) Most of the studies on cancer have tried to explain the observed differential gene expression considering only transcriptional regulation. However, post-transcriptional regulation (PTR) has been increasingly recognized as a complex mechanism that also controls various steps of gene expression regulation. Post-transcritional regulation is governed by the interactions of RNA-binding proteins (RBPs) and microRNAs (miRNAs) with their target genes. In this thesis, having found that several RBPs are differentiall...
Investigation of schizophrenia related genes and pathways through genome wide association studies Döm, Hüseyin Alper; Aydın Son, Yeşim; Department of Bioinformatics (2013) Schizophrenia is a complex mental disorder that is commonly characterized as deterioration of intellectual process and emotional responses and affects 1% of any given population. SNPs are single nucleotide changes that take place in DNA sequences and establish the major percentage of genomic variations. In this study, our goal was to identify SNPs as genomic markers that are related with schizophrenia and investigate the genes and pathways that are identified through the analysis of SNPs. Genome wide associ...
Unique Contributions of Metacognition and Cognition to Depressive Symptoms YILMAZ, ADVİYE ESİN; Gençöz, Tülin; Wells, Adrian (2015-01-01) This study attempts to examine the unique contributions of cognitions or metacognitions to depressive symptoms while controlling for their intercorrelations and comorbid anxiety. Two-hundred-and-fifty-one university students participated in the study. Two complementary hierarchical multiple regression analyses were performed, in which symptoms of depression were regressed on the dysfunctional attitudes (DAS-24 subscales) and metacognition scales (Negative Beliefs about Rumination Scale [NBRS] and Positive B...
INTEGRATION OF MACHINE LEARNING AND ENTROPY METHODS FOR POST-GENOME-WIDE ASSOCIATION STUDIES ANALYSIS Yaldız, Burcu; Aydın Son, Yeşim; Department of Medical Informatics (2022-8-31) Non-linear relationships between genotypes play an essential role in understanding the genetic interactions of complex disease traits. Genome-Wide Association Studies (GWAS) have revealed a statistical association between the SNPs in many complex diseases. As GWAS results could not thoroughly explain the genetic background of these disorders, Genome-Wide Interaction Studies started to gain importance. In recent years, various statistical approaches such as entropy-based methods have been suggested for revea...
Brief report: Autism in individuals with Down syndrome Starr, EM; Kazak Berument, Sibel; Tomlins, M; Papanikolaou, K; Rutter, M (Springer Science and Business Media LLC, 2005-10-01) As an off-shoot of a study examining the reliability and validity of an adapted version of the Pre-Linguistic Autism Diagnostic Observation Schedule (A-PL-ADOS), 13 individuals with Down syndrome with IQs ranging between 24 and 48 were administered the Autism Diagnostic Interview-Revised (ADI-R) and the A-PL-ADOS, which are well-validated interview and observational diagnostic measures. Three out of 13 met lifetime criteria on the ADI-R, but none of these three showed behavior that met the criterion for aut...

Citation Formats

A. CENGİZ HAN, Y. Aydın Son, C. ÇELİK, and T. RECEP, “Evaluation of Whole Genome Association Study Data in Bipolar Disorders: Potential Novel SNPs and Genes,” KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY, pp. 12–18, 2015, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/31685.